INT197493

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Context Info
Confidence 0.79
First Reported 2006
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 61
Total Number 63
Disease Relevance 27.48
Pain Relevance 7.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
macrophages 4
microglia 3
neurons 3
hepatocytes 2
brain 2
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 1472 99.72 Very High Very High Very High
withdrawal 164 99.72 Very High Very High Very High
cINOD 336 96.20 Very High Very High Very High
Inflammation 235 94.32 High High
Central nervous system 199 92.44 High High
agonist 64 92.32 High High
Hippocampus 60 88.08 High High
Bile 4 86.92 High High
cytokine 113 84.76 Quite High
Immobilon 17 83.96 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 1704 100.00 Very High Very High Very High
Targeted Disruption 378 100.00 Very High Very High Very High
Aging 85 99.92 Very High Very High Very High
Amyloid Plaque 95 99.84 Very High Very High Very High
Disease 1775 99.44 Very High Very High Very High
Obesity 388 98.56 Very High Very High Very High
Necrosis 44 97.24 Very High Very High Very High
Cancer 46 96.88 Very High Very High Very High
Cognitive Disorder 273 96.24 Very High Very High Very High
Head Trauma 3 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo, early evidence for an involvement of apoE in AD came from immunohistochemical localization of apoE to senile plaques [24].
Localization (localization) of apoE in plaques associated with disease and amyloid plaque
1) Confidence 0.79 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 1.49 Pain Relevance 0
If HDL, as a whole, functions as a net cholesterol supplier to neurons, what is the biological significance of apoE-HDL-mediated cholesterol release from neurons?
Localization (release) of apoE in neurons associated with disorder of lipid metabolism
2) Confidence 0.77 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.96 Pain Relevance 0.07
ApoE-isoform-specific lipid release mediated by apoE3- and apoE4-containing HDL
Localization (release) of ApoE-isoform associated with disorder of lipid metabolism
3) Confidence 0.77 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.98 Pain Relevance 0
Because our previous study demonstrated that apoE4-HDL contains apoE molecules twofold those in apoE3-HDL per particle [10], we determined the amount of apoE molecules in each HDL fraction added and plotted against the amount of cholesterol and PC released at various apoE concentrations.
Localization (released) of apoE associated with disorder of lipid metabolism
4) Confidence 0.77 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 1.42 Pain Relevance 0.04
Western blotting of hippocampal apoE
Localization (hippocampal) of apoE
5) Confidence 0.75 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0 Pain Relevance 0.15
In brain, apoE is mainly synthesized and secreted by astrocytes and microglia (Boyles et al., 1985).
Localization (secreted) of apoE in microglia
6) Confidence 0.74 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912027 Disease Relevance 0.61 Pain Relevance 0.28
burden are seen in mice as well, with studies in mice deficient for apoE or transgenic for human apoE supporting a role for apoE in A?
Localization (transgenic) of apoE associated with targeted disruption
7) Confidence 0.73 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 1.04 Pain Relevance 0
Preparation of lipid emulsions (EM) and apoE-EM complex
Localization (Preparation) of apoE
8) Confidence 0.71 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.06 Pain Relevance 0
Because our previous study demonstrated that apoE4-HDL contains apoE molecules twofold those in apoE3-HDL per particle [10], we determined the amount of apoE molecules in each HDL fraction added and plotted against the amount of cholesterol and PC released at various apoE concentrations.
Localization (released) of apoE associated with disorder of lipid metabolism
9) Confidence 0.71 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 1.45 Pain Relevance 0.04
Interestingly, the apoE-EM complex at certain apoE concentrations and apoE/EM particle ratios induces cholesterol release in an apoE-isoform-specific manner; apoE-EM3 induces cholesterol release, but apoE4-EM does not (Fig. 4), as observed in the cases of apoE3-HDL and apoE4-HDL (Fig. 1).
Localization (release) of apoE-isoform associated with disorder of lipid metabolism
10) Confidence 0.71 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.91 Pain Relevance 0
One may question, which is the net cholesterol transport, release from or supply to cells, in the presence of apoE-HDL and apoE-EM?
Localization (presence) of apoE associated with disorder of lipid metabolism
11) Confidence 0.71 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.98 Pain Relevance 0.09
g/ml, respectively (Table 1), the apoE-isoform-specific cholesterol release was observed (Fig. 4) as was the case for apoE-HDL (Fig. 1), that is, apoE3-EM and apoE3-HDL induced cholesterol release from neurons, whereas apoE4-EM and apoE4-HDL induced little release.
Localization (release) of apoE-isoform in neurons associated with disorder of lipid metabolism
12) Confidence 0.71 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.29 Pain Relevance 0
The ratio of ratio of PC per apoE at apoE concentrations of 0.1,1,10, and 30 ?
Localization (ratio) of apoE
13) Confidence 0.71 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.11 Pain Relevance 0
For the determination of the concentration of apoE released into the culture medium, signals corresponding to apoE of each sample in the immunoblot membrane were quantified by densitometry using NIH image software, at varying concentrations of synthetic apoE protein (Wako, Tokyo, Japan) as standards.
Localization (released) of apoE
14) Confidence 0.71 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.09 Pain Relevance 0.04
Interestingly, the apoE-EM complex at certain apoE concentrations and apoE/EM particle ratios induces cholesterol release in an apoE-isoform-specific manner; apoE-EM3 induces cholesterol release, but apoE4-EM does not (Fig. 4), as observed in the cases of apoE3-HDL and apoE4-HDL (Fig. 1).
Localization (release) of apoE associated with disorder of lipid metabolism
15) Confidence 0.71 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.92 Pain Relevance 0
As a mechanism underlying this apoE-isoform specificity, we showed a novel action of apoE, that is, although apoE is a lipid acceptor, when apoE is associated with lipid particles such as HDL and EM, apoE inhibits lipid-particle-mediated cholesterol release in an apoE-dose-dependent manner.
Localization (release) of apoE associated with disorder of lipid metabolism
16) Confidence 0.71 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.63 Pain Relevance 0.04
g/ml, respectively (Table 1), the apoE-isoform-specific cholesterol release was observed (Fig. 4) as was the case for apoE-HDL (Fig. 1), that is, apoE3-EM and apoE3-HDL induced cholesterol release from neurons, whereas apoE4-EM and apoE4-HDL induced little release.
Localization (release) of apoE in neurons associated with disorder of lipid metabolism
17) Confidence 0.71 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.30 Pain Relevance 0
ApoE-dose-dependent inhibition of EM-mediated lipid release
Localization (release) of ApoE-dose-dependent
18) Confidence 0.71 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.11 Pain Relevance 0
Moreover, as we previously reported [10], apoE4-HDL contains number of apoE molecules per particle twofold that of apoE3; however, apoE4-HDL induced a very-weak cholesterol release, whereas apoE3-HDL induced a strong cholesterol release (Figs. 1A and 1B).
Localization (release) of apoE associated with disorder of lipid metabolism
19) Confidence 0.71 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 1.26 Pain Relevance 0.04
For the determination of the concentration of apoE released into the culture medium, signals corresponding to apoE of each sample in the immunoblot membrane were quantified by densitometry using NIH image software, at varying concentrations of synthetic apoE protein (Wako, Tokyo, Japan) as standards.
Localization (released) of apoE
20) Confidence 0.71 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.07 Pain Relevance 0.04

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