INT197494

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 7.33
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoa4) transport (Apoa4) extracellular space (Apoa4)
extracellular region (Apoa4) cytoplasm (Apoa4)
Anatomy Link Frequency
macrophages 1
Neuronal 1
neuron 1
astrocytes 1
Apoa4 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 16 97.24 Very High Very High Very High
chemokine 4 93.52 High High
Thalamus 40 91.76 High High
Hippocampus 107 86.28 High High
cytokine 28 73.80 Quite High
dorsal root ganglion 1 71.76 Quite High
cINOD 123 70.60 Quite High
Central nervous system 12 59.12 Quite High
Inflammation 150 58.96 Quite High
agonist 27 50.00 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 30 100.00 Very High Very High Very High
Targeted Disruption 880 99.78 Very High Very High Very High
Apoptosis 29 99.68 Very High Very High Very High
Disease 529 99.12 Very High Very High Very High
Neurodegenerative Disease 88 98.32 Very High Very High Very High
Stress 49 98.24 Very High Very High Very High
Amyloid Plaque 205 97.16 Very High Very High Very High
Alzheimer's Dementia 824 93.52 High High
Injury 10 92.40 High High
Anaplastic Astrocytoma 3 84.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From this list of ten transcripts, we additionally tested IGF-BP2, flavin-containing monoxygenase 3 (FMO3), and apolipoprotein A-IV (APOAIV) expression.
Gene_expression (expression) of APOAIV associated with disorder of lipid metabolism
1) Confidence 0.05 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.24 Pain Relevance 0
The next series of experiments used primary cultures derived from transgenic mice that express apoE3 or apo4 under the glial fibrillary acidic protein promoter.
Gene_expression (express) of apo4 associated with targeted disruption
2) Confidence 0.03 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.33 Pain Relevance 0.07
They also produce apolipoprotein E4 (apoE4) that aggravates A?
Gene_expression (produce) of apoE4 associated with disorder of lipid metabolism
3) Confidence 0.02 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 1.11 Pain Relevance 0.05
ApoE4 is also produced by astrocytes and aggravates A?
Gene_expression (produced) of ApoE4 in astrocytes
4) Confidence 0.02 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 0.60 Pain Relevance 0
They also produce apolipoprotein E4 (apoE4) that aggravates A?
Gene_expression (produce) of apolipoprotein E4 associated with disorder of lipid metabolism
5) Confidence 0.02 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 1.11 Pain Relevance 0.05
In various transgenic lines in which human ApoE3 or ApoE4 was expressed under a GFAP or a neuron-specific enolase (NSE) promoter, C-terminal fragments of ApoE4 (and to a lesser degree of ApoE3) accumulated, and tau protein appeared to be hyperphosphorylated only in the NSE-ApoE Tg mice [34].


Gene_expression (expressed) of ApoE4 in neuron associated with targeted disruption
6) Confidence 0.01 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.40 Pain Relevance 0.17
The overexpression of ApoE4 in a hAPP mouse, knocked out for ApoE, increases the number of focal, amyloid deposits tenfold in comparison with the ApoE3 mice [133].
Gene_expression (overexpression) of ApoE4 associated with amyloid plaque
7) Confidence 0.01 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.71 Pain Relevance 0
Neuronal but not glial expression of ApoE4 resulted in hyperphosphorylation of protein tau and caused prominent axonopathy by disrupting axonal transport [299, 300].
Gene_expression (expression) of ApoE4 in Neuronal
8) Confidence 0.01 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.43 Pain Relevance 0.19
Recently, it has been suggested that the ApoE allele could play a role, since environmental enrichment stimulated apoptosis when the human ApoE4 was expressed on a murine ApoE deficient background, while it stimulated neurogenesis in ApoE3 mice [194].


Gene_expression (expressed) of ApoE4 associated with neurodegenerative disease and apoptosis
9) Confidence 0.01 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 1.29 Pain Relevance 0.04
, the expression of the human ApoE4 (ApoE4+/?)
Gene_expression (expression) of ApoE4
10) Confidence 0.01 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.81 Pain Relevance 0
than apoE3-expressing, apoE4-expressing, or apoE-deficient macrophages (Zhao et al., 2009).
Gene_expression (expressing) of apoE4-expressing in macrophages
11) Confidence 0.01 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912027 Disease Relevance 0.28 Pain Relevance 0.21

General Comments

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