INT197495

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.19
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
brain 4
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 10 99.38 Very High Very High Very High
dexamethasone 92 97.56 Very High Very High Very High
Hippocampus 12 88.08 High High
agonist 4 85.24 High High
Pyramidal cell 7 78.96 Quite High
Peripheral nervous system 5 68.60 Quite High
Neuritis 25 59.20 Quite High
Intracerebroventricular 18 54.88 Quite High
addiction 3 39.36 Quite Low
anesthesia 2 26.00 Quite Low
Disease Link Frequency Relevance Heat
Disease 119 99.44 Very High Very High Very High
Cognitive Disorder 23 96.24 Very High Very High Very High
Disorder Of Lipid Metabolism 109 91.00 High High
Targeted Disruption 49 88.48 High High
Amyloid Plaque 14 85.88 High High
Syndrome 19 85.60 High High
Experimental Autoimmune Neuritis 24 59.20 Quite High
Aging 4 57.92 Quite High
Obesity 24 50.68 Quite High
Alzheimer's Dementia 17 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As there is limited permeability of the BBB to lipoproteins [14, 128, 129], this change might be due to a decrease of local apoE synthesis and secretion by brain tissue, as part of systemic decrease of apoE synthesis in acute phage reaction [4].
Negative_regulation (decrease) of Localization (secretion) of apoE in brain
1) Confidence 0.43 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.72 Pain Relevance 0.13
Western blotting of hippocampal apoE
Negative_regulation (blotting) of Localization (hippocampal) of apoE
2) Confidence 0.43 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0 Pain Relevance 0.15
ApoE-dose-dependent inhibition of EM-mediated lipid release
Negative_regulation (inhibition) of Localization (release) of ApoE-dose-dependent
3) Confidence 0.41 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.11 Pain Relevance 0
, ApoE and phosphorylated tau are also found in brains of AD patients.22

A?

Negative_regulation (tau) of Localization (found) of ApoE in brains associated with disease
4) Confidence 0.25 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938309 Disease Relevance 1.11 Pain Relevance 0
M with insignificant reduction in ApoE secretion (Figure 5a).
Negative_regulation (reduction) of Localization (secretion) of ApoE
5) Confidence 0.19 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.11 Pain Relevance 0.22
Upon withdrawal of the inductive stimuli, the ApoE secretion persisted for a further 14 days.


Negative_regulation (persisted) of Localization (secretion) of ApoE associated with withdrawal
6) Confidence 0.14 Published 2008 Journal BMC Biotechnol Section Abstract Doc Link PMC2596794 Disease Relevance 0.13 Pain Relevance 0.23

General Comments

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