INT197496

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 2.32
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Apoe, Lrp1) endosome (Lrp1) transport (Apoe)
aging (Apoe) Golgi apparatus (Apoe) lipid metabolic process (Apoe)
Anatomy Link Frequency
astrocyte 2
glial cells 1
Neurons 1
brain 1
Apoe (Mus musculus)
Lrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 58 93.68 High High
Multiple sclerosis 5 76.48 Quite High
Intracerebroventricular 32 75.76 Quite High
Peripheral nervous system 5 53.96 Quite High
Sciatic nerve 1 50.96 Quite High
Neuritis 24 32.44 Quite Low
Hippocampus 54 30.00 Quite Low
dorsal root ganglion 2 6.48 Low Low
Inflammation 88 5.00 Very Low Very Low Very Low
Kinase C 72 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 445 92.76 High High
Amyloid Plaque 32 92.52 High High
Disorder Of Lipid Metabolism 46 91.48 High High
Heart Disease 12 86.56 High High
Increased Venous Pressure Under Development 80 85.96 High High
Congenital Anomalies 24 82.80 Quite High
Syndrome 19 77.12 Quite High
Multiple Sclerosis 6 76.48 Quite High
Targeted Disruption 43 72.16 Quite High
Drug Induced Neurotoxicity 10 71.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like the enhanced neurotrophic action of apoE3, our cell culture data suggest that the greater neurotrophic actions of apoE2 may derive, at least in part, from astrocyte-secreted apoE2 and may be dependent on apoE2-LRP interaction.
apoE2 Binding (interaction) of LRP in astrocyte
1) Confidence 0.22 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.16 Pain Relevance 0.07
Like the enhanced neurotrophic action of apoE3, our cell culture data suggest that the greater neurotrophic actions of apoE2 may derive, at least in part, from astrocyte-secreted apoE2 and may be dependent on apoE2-LRP interaction.
apoE2 Binding (interaction) of LRP in astrocyte
2) Confidence 0.22 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.16 Pain Relevance 0.07
Moreover, the lipid-free apoE was shown only to bind LRP [93, 170, 171].
apoE Binding (bind) of LRP
3) Confidence 0.16 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.49 Pain Relevance 0.12
ApoE binds cholesterol and acts as a ligand for cell surface-lipoprotein receptors such as LDL-receptor-related proteins (LRP), illustrated in (Fig. 8).
ApoE Binding (ligand) of LRP
4) Confidence 0.04 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.49 Pain Relevance 0.07
Neurons and glial cells contain LRP receptors, which are large endocytic membrane receptors that can bind and internalise the ApoE-cholesterol phospholipid complex and then fuse with lysosomes.
ApoE Binding (bind) of LRP in glial cells
5) Confidence 0.04 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.34 Pain Relevance 0.05
can be transported across the BBB and exported out of the brain into the bloodstream either by directly binding to LRP or by binding to the LRP ligands ApoE and ?
ApoE Binding (binding) of LRP in brain
6) Confidence 0.04 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.33 Pain Relevance 0.04
Neurons and glial cells contain LRP receptors, which are large endocytic membrane receptors that can bind and internalise the ApoE-cholesterol phospholipid complex and then fuse with lysosomes.
ApoE Binding (bind) of LRP in Neurons
7) Confidence 0.01 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.34 Pain Relevance 0.05

General Comments

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