INT1975

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Context Info
Confidence 0.59
First Reported 1978
Last Reported 2006
Negated 7
Speculated 6
Reported most in Abstract
Documents 32
Total Number 38
Disease Relevance 5.78
Pain Relevance 18.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
plasma 9
pituitary 4
EPI 2
neuronal 2
blood 2
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 140 100.00 Very High Very High Very High
Opioid 67 100.00 Very High Very High Very High
antagonist 36 100.00 Very High Very High Very High
opiate 32 100.00 Very High Very High Very High
Endogenous opioid 18 100.00 Very High Very High Very High
Clonidine 5 100.00 Very High Very High Very High
transcutaneous nerve stimulation 1 100.00 Very High Very High Very High
rapifen 10 99.92 Very High Very High Very High
Serotonin 12 99.84 Very High Very High Very High
GABAergic 4 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoglycemia 20 100.00 Very High Very High Very High
Post Operative Pain 3 98.76 Very High Very High Very High
Galactorrhea 7 98.50 Very High Very High Very High
Obesity 18 98.48 Very High Very High Very High
Stress 20 97.80 Very High Very High Very High
Pain 5 91.08 High High
Hypopituitarism 1 86.52 High High
Body Weight 2 86.48 High High
Shock 1 81.76 Quite High
Injury 4 77.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in frontal muscle electromyogram or plasma cortisol and prolactin levels were not dependent on the adjuvant used.
Neg (not) Regulation (dependent) of Regulation (Changes) of prolactin in plasma
1) Confidence 0.59 Published 1985 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 3919524 Disease Relevance 0 Pain Relevance 0.48
These data suggest the involvement of a GABAergic mechanism in the regulation of GH and PRL responses to physical exercise in men.
Regulation (regulation) of Regulation (responses) of PRL associated with gabaergic
2) Confidence 0.49 Published 1994 Journal Eur. J. Endocrinol. Section Abstract Doc Link 8038904 Disease Relevance 0 Pain Relevance 0.82
These studies demonstrate that opiates mediate their stimulatory effects on PRL release, at least in part, through a serotonergic mechanism in adult rats.
Regulation (mediate) of Regulation (effects) of PRL associated with opiate
3) Confidence 0.45 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2435887 Disease Relevance 0 Pain Relevance 1.19
We, therefore, examined the effect of hyperprolactinemia on the density of naloxone binding sites in hypothalamic regions that are important in the regulation of PRL and LH secretion.
Regulation (important) of Regulation (regulation) of PRL associated with galactorrhea and narcan
4) Confidence 0.45 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2559342 Disease Relevance 0.43 Pain Relevance 0.55
Sodium ions: their role and mechanism of action in the control of prolactin release.
Regulation (role) of Regulation (control) of prolactin
5) Confidence 0.45 Published 1984 Journal Endocrinology Section Title Doc Link 6423371 Disease Relevance 0 Pain Relevance 0.13
These results clearly indicate that opioids are involved not only in the regulation of GH and PRL release but also in the gene expression of the two hormones.
Regulation (involved) of Regulation (regulation) of PRL associated with opioid
6) Confidence 0.45 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680424 Disease Relevance 0 Pain Relevance 1.25
In order to investigate the role of opioids in the regulation of PRL and GH gene expression in the rat pituitary, we studied the effects of chronic administration of the opioid drug morphine and an opiate receptor antagonist naloxone on both PRL and GH gene expression as measured by in situ hybridization.
Spec (investigate) Regulation (role) of Spec (investigate) Regulation (regulation) of PRL in pituitary associated with antagonist, narcan, opiate, opioid and morphine
7) Confidence 0.45 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680424 Disease Relevance 0 Pain Relevance 0.95
The role of nerve cells of the arcuate nucleus and endogenous opioid peptides in the regulation of GH and prolactin secretion has been investigated.
Regulation (role) of Regulation (regulation) of prolactin in arcuate nucleus associated with endogenous opioid
8) Confidence 0.43 Published 1983 Journal J. Endocrinol. Section Abstract Doc Link 6833931 Disease Relevance 0 Pain Relevance 0.37
Around the time of ovulation there is a surge of luteinizing hormone (LH) and changes in serum levels of prolactin, possibly due to an increase in estrogen secretion during the preovulatory period.
Spec (possibly) Regulation (surge) of Regulation (changes) of prolactin
9) Confidence 0.43 Published 1980 Journal J. Reprod. Fertil. Section Abstract Doc Link 6776267 Disease Relevance 0.24 Pain Relevance 0.28
The effect of naloxone on endogenous opioid regulation of pituitary gonadotropins and prolactin during the menstrual cycle.
Regulation (effect) of Regulation (regulation) of prolactin in pituitary associated with endogenous opioid and narcan
10) Confidence 0.41 Published 1984 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 6330154 Disease Relevance 0 Pain Relevance 0.53
Naloxone treatment failed to alter serum LH concentrations in EF, LF, or OVX gilts and PRL concentrations in OVX gilts.
Neg (failed) Regulation (alter) of Regulation (concentrations) of PRL associated with narcan
11) Confidence 0.33 Published 1986 Journal Biol. Reprod. Section Abstract Doc Link 3828431 Disease Relevance 0.06 Pain Relevance 0.48
Pretreatment with naloxone did not affect the responses of GH, PRL, or cortisol to hypoglycemia or the PRL response to L-dopa.
Neg (not) Regulation (affect) of Neg (not) Regulation (responses) of PRL associated with hypoglycemia and narcan
12) Confidence 0.32 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6244322 Disease Relevance 0.34 Pain Relevance 0.43
Pretreatment with naloxone did not affect the responses of GH, PRL, or cortisol to hypoglycemia or the PRL response to L-dopa.
Neg (not) Regulation (affect) of Neg (not) Regulation (responses) of PRL associated with hypoglycemia and narcan
13) Confidence 0.32 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6244322 Disease Relevance 0.34 Pain Relevance 0.43
Naloxone did not modify the PRL and GH response but provoked a rise in the cortisol response in both obese and normal weight subjects.
Neg (not) Regulation (modify) of Neg (not) Regulation (response) of PRL associated with obesity and narcan
14) Confidence 0.29 Published 1989 Journal J. Endocrinol. Invest. Section Abstract Doc Link 2693516 Disease Relevance 0.85 Pain Relevance 0.57
In order to verify this hypothesis we studied the effect of iv naloxone, an opiate receptor antagonist, on GH, PRL and cortisol response to insulin-induced hypoglycemia in 9 obese female subjects.
Regulation (effect) of Regulation (response) of PRL associated with hypoglycemia, antagonist, obesity, narcan and opiate
15) Confidence 0.29 Published 1989 Journal J. Endocrinol. Invest. Section Abstract Doc Link 2693516 Disease Relevance 0.78 Pain Relevance 0.52
We explored the role of the opioid system and the participation of ovarian hormones in the regulation of prolactin induced by the suckling stimulus at the end of pregnancy in rats with developed maternal behavior, and during lactation.
Regulation (role) of Regulation (regulation) of prolactin associated with opioid
16) Confidence 0.27 Published 2002 Journal J. Endocrinol. Section Abstract Doc Link 11834443 Disease Relevance 0 Pain Relevance 0.38
The maximal effects of DOI and clonidine on plasma corticosterone or prolactin levels were not affected by ipsapirone pretreatment.
Neg (not) Regulation (affected) of Regulation (effects) of prolactin in plasma associated with clonidine
17) Confidence 0.27 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8095465 Disease Relevance 0.31 Pain Relevance 0.47
These effects may involve alterations in the regulation of Prl-inhibiting factor or Prl-stimulating factor.
Regulation (alterations) of Regulation (regulation) of Prl
18) Confidence 0.27 Published 1981 Journal Brain Res. Section Abstract Doc Link 7260607 Disease Relevance 0.15 Pain Relevance 0.16
These results suggest that endogenous opioid peptides may have a role in regulating the PRL and LH surges during proestrus in the rat.
Regulation (role) of Regulation (regulating) of PRL associated with endogenous opioid
19) Confidence 0.27 Published 1980 Journal Endocrinology Section Abstract Doc Link 6767598 Disease Relevance 0 Pain Relevance 0.91
Serotonin (5-HT) is involved in the neuroendocrine regulation of prolactin (PRL) secretion as a stimulator.
Regulation (involved) of Regulation (regulation) of PRL associated with serotonin
20) Confidence 0.27 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1386914 Disease Relevance 0 Pain Relevance 0.24

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