INT197501

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Context Info
Confidence 0.76
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 15
Disease Relevance 3.08
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr3) intracellular (Egr3) DNA binding (Egr3)
Anatomy Link Frequency
hippocampus 3
neuronal 1
brain 1
nucleus 1
leaflets 1
Egr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 80 99.78 Very High Very High Very High
Central nervous system 16 95.44 Very High Very High Very High
Pyramidal cell 8 86.96 High High
medulla 8 85.44 High High
amygdala 16 82.80 Quite High
long-term potentiation 64 70.40 Quite High
dopamine receptor 16 61.28 Quite High
withdrawal 16 59.44 Quite High
opiate 16 59.00 Quite High
Eae 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 33 99.68 Very High Very High Very High
Cognitive Disorder 160 95.88 Very High Very High Very High
Targeted Disruption 72 95.60 Very High Very High Very High
Shock 160 94.64 High High
Anxiety Disorder 214 89.32 High High
Appetite Loss 64 88.72 High High
Polyps 6 74.36 Quite High
Colorectal Cancer 186 73.68 Quite High
Brain Hemorrhage 16 64.80 Quite High
Recurrence 10 63.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found no change in basal, constitutive levels of Egr1 or Egr3 protein expression, or in seizure-induced expression, in either area CA1 of the hippocampus or the dentate gyrus in cKO or HT mice, indicating that at least in hippocampal regions the absence of one or two Egr2 alleles is not associated with overexpression of these other Egr family members.
Gene_expression (expression) of Egr3 in hippocampus associated with convulsion and hippocampus
1) Confidence 0.76 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.66 Pain Relevance 0.17
Thus, it is possible that Egr2, which seems expressed at lower levels than Egr1 and Egr3 in most brain regions as confirmed here in the dentate gyrus and area CA1 of the hippocampus, is not, or is less responsive to physiological neuronal activity during learning and is therefore dispensable for learning and memory.
Gene_expression (expressed) of Egr3 in neuronal associated with hippocampus
2) Confidence 0.76 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.32 Pain Relevance 0.23
These results clearly do not extend the phenotypic consequences resulting from either Egr1 or Egr3 loss-of-function to Egr2.
Gene_expression (loss) of Egr3
3) Confidence 0.66 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Abstract Doc Link PMC2525857 Disease Relevance 0.57 Pain Relevance 0
Western blotting analyses were conducted to assess constitutive and regulated levels of Egr1, Egr2 and Egr3 in the dentate gyrus and CA1 of the hippocampus from WT, HT and cKO mice (n?
Gene_expression (levels) of Egr3 in hippocampus associated with hippocampus
4) Confidence 0.66 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.05
Analyses of basal and brain stimulation-induced expression of other Egr family members suggest that the absence of deficits and the gain of function in certain tasks in Egr2-deficient mice is not due to compensatory expression of Egr1 or Egr3.


Gene_expression (expression) of Egr3 in brain
5) Confidence 0.66 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.24 Pain Relevance 0
This suggests that in the absence of Egr2 there is neither compensatory regulation nor a linked detrimental effect on expression of Egr1 and Egr3.
Gene_expression (expression) of Egr3
6) Confidence 0.59 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.40 Pain Relevance 0.03
In contrast to Egr1 and Egr3, Egr2 protein has been detected in both the nucleus and cytoplasm of forebrain neurons (De et al., 2003; Mack et al., 1992).
Gene_expression (detected) of Egr3 in nucleus
7) Confidence 0.26 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.26
In area CA1 of the hippocampus, Egr1 and Egr3 were constitutively expressed while the Egr2 antibody detected only a weak signal that was close to background (Figure 7D).
Gene_expression (tutively ) of Egr3 in hippocampus associated with hippocampus
8) Confidence 0.26 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.54 Pain Relevance 0.05
Most pilot and non-pilot GPs expressed the desire for accessible statistical information about the screening programme to be made available to them in order to fully inform patients.
Gene_expression (expressed) of pilot
9) Confidence 0.22 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1584239 Disease Relevance 0 Pain Relevance 0
Most pilot and non-pilot GPs expressed the desire for accessible statistical information about the screening programme to be made available to them in order to fully inform patients.
Gene_expression (expressed) of pilot
10) Confidence 0.22 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1584239 Disease Relevance 0 Pain Relevance 0
(PILOT 14)

Patient participation

Gene_expression (participation) of PILOT
11) Confidence 0.22 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1584239 Disease Relevance 0.08 Pain Relevance 0
Although patient information leaflets were available in a variety of languages during the pilot, two GPs whose practices covered large ethnic minority populations did notice increase in patient numbers:

"Well I mean there was a fair amount of work involved because patients would bring all these forms to us and say 'what's this?'

Gene_expression (available) of pilot in leaflets
12) Confidence 0.19 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1584239 Disease Relevance 0.15 Pain Relevance 0
While fully endorsing informed choice as a concept, a minority of the non-pilot GPs questioned the reality of promoting it in practice:

"...

Gene_expression (questioned) of pilot
13) Confidence 0.19 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1584239 Disease Relevance 0 Pain Relevance 0
Many of the pilot GPs had little recollection of the information pack provided to them during the course of the pilot, and indicated that they had used it only rarely.
Gene_expression (Many) of pilot
14) Confidence 0.19 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1584239 Disease Relevance 0 Pain Relevance 0
Therefore estimates of different outcomes are performed using a pilot MRCT comparing 50 versus 50 randomized patients in order to establish a hypothesis that can be tested thereafter.
Gene_expression (using) of pilot
15) Confidence 0.07 Published 2007 Journal Trials Section Body Doc Link PMC2075519 Disease Relevance 0.13 Pain Relevance 0

General Comments

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