INT197512

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 7.08
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCA4) ATPase activity (ABCA4) plasma membrane (ABCA4)
transmembrane transport (ABCA4)
Anatomy Link Frequency
eye 2
ectoderm 1
choroid plexus 1
subcutaneous adipose tissue 1
photoreceptor cells 1
ABCA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 48 78.72 Quite High
Osteoarthritis 32 58.24 Quite High
Inflammation 32 58.16 Quite High
addiction 24 57.20 Quite High
cva 13 52.00 Quite High
Pain 25 44.56 Quite Low
anesthesia 1 43.36 Quite Low
Neuritis 6 27.36 Quite Low
agonist 5 13.76 Low Low
tolerance 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 557 100.00 Very High Very High Very High
Disease 308 100.00 Very High Very High Very High
Age-related Macular Degeneration 134 98.80 Very High Very High Very High
Eye Disease 126 98.10 Very High Very High Very High
Overweight 143 96.56 Very High Very High Very High
Cognitive Disorder 5 94.60 High High
Disorder Of Lipid Metabolism 25 94.12 High High
Epstein-barr Virus 84 93.56 High High
Hydrocephalus 36 91.64 High High
Neurosis 17 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The benefit of finding a genetic association with specific genes is that we can begin to understand more about how the parasite triggers the development of ocular disease during embryogenesis and fetal development by examining what is known about the chronological expression and localization of COL2A1 and ABCA4 during development and after birth.
Gene_expression (expression) of ABCA4 associated with eye disease
1) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 1.44 Pain Relevance 0.03
Of interest too is the observation is that ABCA4 is selectively expressed in the choroid plexus throughout development [39], [40], suggesting a possible role for ABCA4 in determining pathology in brain in addition to eye, that would be consistent with the association observed with hydrocephalus, in particular when examining associations between mother's genotype and clinical outcome in the child for the European cohort.
Gene_expression (expressed) of ABCA4 in choroid plexus associated with hydrocephalus
2) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.29 Pain Relevance 0
Less is known about the chronological pattern of expression of ABCA4 in the eye during development compared to COL2A1, although a high frequency of cDNA clones positive for ABCA4 has been reported in screens of cDNA libraries prepared from developing mouse eye [38].
Gene_expression (expression) of ABCA4 in eye
3) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.21 Pain Relevance 0
It can be therefore envisaged that expression of wild-type ABCA4 in iPSCs derived from well-characterized STGD patients with ABCA4 mutations and their further differentiation to RPE and photoreceptor cells could potentially elicit some clinical improvement.
Gene_expression (expression) of ABCA4 in photoreceptor cells associated with disease
4) Confidence 0.72 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0.46 Pain Relevance 0.03
We found evidence of isoform-specific monoallelic expression of alleles at both genes, which for ABCA4 was also polymorphic.
Gene_expression (expression) of ABCA4
5) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.36 Pain Relevance 0
RT/PCR analysis demonstrated that ABCA4 and COL2A1 were expressed in human embryonic stem cell lines before and after commitment to extra-embryonic or ectoderm/ neural lineages, and in human placenta but not uterus (Figure 2A and 2B).
Gene_expression ( were exp) of ABCA4 in neural
6) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.34 Pain Relevance 0
A2E, which accumulates in the STGD eye, is also found in the RPE in AMD and perturbs efflux of cholesterol from RPE endosomes/lysosomes, causing cholesterol and cholesteryl ester deposit accumulation [61,126,127].
Gene_expression (eye) of STGD in eye associated with age-related macular degeneration and disease
7) Confidence 0.54 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 1.09 Pain Relevance 0
A similar shift in fasting substrate use was noted in both groups, either expressed in g/h or mg/kg FFM/h.
Gene_expression (expressed) of FFM
8) Confidence 0.42 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584255 Disease Relevance 0 Pain Relevance 0
2.4 kg change in FFM (95% CI, ?
Gene_expression (change) of FFM
9) Confidence 0.42 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584255 Disease Relevance 0 Pain Relevance 0
As expected, FFM was a determinant of RMR in both groups during both the ambulatory and bed-rest periods (Pearson r = 0.65; p < 0.01, and r = 0.59; p < 0.01, respectively).
Gene_expression (expected) of FFM
10) Confidence 0.42 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584255 Disease Relevance 0 Pain Relevance 0
Expressed in mg/kg FFM and cumulative for both groups, postprandial glucose oxidation increased by 124 mg/kg FFM (95% CI, 28 to 220 mg/kg FFM; Wilcoxon sign-rank test p = 0.005) and lipid oxidation decreased by 36% (?
Gene_expression (Expressed) of FFM
11) Confidence 0.42 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584255 Disease Relevance 0 Pain Relevance 0
A second finding of this study is that a low relative fat free mass (FFM), expressed as kg of FFM × body height (m)?
Gene_expression (expressed) of FFM in body
12) Confidence 0.41 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2990021 Disease Relevance 0.60 Pain Relevance 0.06
Also, the FFM has been reproduced in a number of culturally different countries [16-18], indicating a universally valid structure.
Gene_expression (reproduced) of FFM
13) Confidence 0.39 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC1959226 Disease Relevance 0.42 Pain Relevance 0.46
The 7 h postmeal cumulative substrate use expressed in g or mg/kg FFM showed the same pattern of response (Table 4).
Gene_expression (expressed) of FFM
14) Confidence 0.38 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584255 Disease Relevance 0 Pain Relevance 0
Interestingly, Aucouturier et al. [30] showed that the FFM is higher in OB children in comparison to NW children and that the power generated per unit of FFM is the same in both groups.
Gene_expression (higher) of FFM associated with obesity
15) Confidence 0.35 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2990021 Disease Relevance 0.46 Pain Relevance 0
RT/PCR analysis demonstrated that ABCA4 and COL2A1 were expressed in human embryonic stem cell lines before and after commitment to extra-embryonic or ectoderm/ neural lineages, and in human placenta but not uterus (Figure 2A and 2B).
Gene_expression ( were exp) of ABCA4 in ectoderm
16) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.34 Pain Relevance 0
In the lean subjects, we found significant correlations between SELS gene expression in subcutaneous adipose tissue and waist circumference, sagittal diameter, FFM, as well as systolic and diastolic BP after adjusting for age and sex (Table 2).
Gene_expression (expression) of FFM in subcutaneous adipose tissue associated with obesity
17) Confidence 0.13 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.86 Pain Relevance 0
Our group [15], and others [13], have found that CrM supplementation during a resistance exercise training program increased FFM gains and some measures of strength in older adults.
Gene_expression (gains) of FFM
18) Confidence 0.12 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0.13 Pain Relevance 0
1 FFM · min?
Gene_expression (min) of FFM
19) Confidence 0.09 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox