INT197545

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.80
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (KEAP1, NFE2L2) cytoplasm (KEAP1, NFE2L2) cytosol (NFE2L2)
endoplasmic reticulum (KEAP1) nucleolus (KEAP1) plasma membrane (NFE2L2)
KEAP1 (Homo sapiens)
NFE2L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 23 98.20 Very High Very High Very High
Lung Cancer 108 86.68 High High
Cancer 208 86.00 High High
Non-small-cell Lung Cancer 48 46.88 Quite Low
Nicotine Addiction 6 25.00 Low Low
Disease 6 25.00 Low Low
Death 4 25.00 Low Low
Adenocarcinoma 16 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 8 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kelch-like ECH-associated protein 1 (KEAP1) negatively regulates NRF2 activity by targeting it to proteasomal degradation.
KEAP1 Regulation (regulates) of NRF2
1) Confidence 0.49 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1584412 Disease Relevance 0.40 Pain Relevance 0
Kelch-like ECH-associated protein 1 (KEAP1) negatively regulates NRF2 activity by targeting it to proteasomal degradation.
ECH-associated protein 1 Regulation (regulates) of NRF2
2) Confidence 0.43 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1584412 Disease Relevance 0.40 Pain Relevance 0
The activity of Nrf2 is regulated by the Cul3 adaptor Keap1, yet little is known regarding mechanisms of regulation of Keap1 itself.
Keap1 Regulation (regulated) of Nrf2
3) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0

General Comments

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