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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (NFE2L2, ABCC2) transport (ABCC2) DNA binding (NFE2L2)
transmembrane transport (ABCC2) cytoplasm (NFE2L2) cytosol (NFE2L2)
Anatomy Link Frequency
plasma 2
NFE2L2 (Homo sapiens)
ABCC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 88.16 High High
palliative 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 104 99.10 Very High Very High Very High
Injury 1 88.80 High High
INFLAMMATION 2 88.16 High High
Apoptosis 3 87.04 High High
Lung Cancer 54 51.12 Quite High
Breast Cancer 1 49.44 Quite Low
Reprotox - General 1 1 47.60 Quite Low
Mouth Cancer 1 45.84 Quite Low
Bladder Cancer 1 43.68 Quite Low
Repression 1 21.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduced chemosensitivity of cancer cells with high NRF2 activity suggests that NRF2 contributes to drug resistance by regulating the expression of several plasma membrane efflux pumps, such as MRP1 and MRP2, and phase II detoxification enzymes.

NRF2 Regulation (regulating) of Gene_expression (expression) of MRP2 in plasma associated with cancer
1) Confidence 0.17 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.72 Pain Relevance 0.04

General Comments

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