INT197547

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.23
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PTS, KEAP1) mitochondrion (PTS) small molecule metabolic process (PTS)
lyase activity (PTS) endoplasmic reticulum (KEAP1) cytosol (PTS)
PTS (Homo sapiens)
KEAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 104 100.00 Very High Very High Very High
Non-small-cell Lung Cancer 24 93.16 High High
Adenocarcinoma 7 81.92 Quite High
Nicotine Addiction 3 78.20 Quite High
Lung Cancer 54 68.88 Quite High
Hyperplasia 1 49.12 Quite Low
Cleidocranial Dysplasia 1 48.08 Quite Low
Carcinoma In Situ 1 46.88 Quite Low
Carcinoma 1 42.64 Quite Low
Stress 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Five of the six PTs harboring KEAP1 mutations showed LOH of KEAP1; thus, as defined by the Knudson two-hit model, there was biallelic inactivation of KEAP1 in these tumors [32].
PTs Binding (harboring) of KEAP1 associated with cancer
1) Confidence 0.08 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 1.23 Pain Relevance 0

General Comments

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