INT197554

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.86
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA4) plasma membrane (ITGA4)
ITGA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 104 95.28 Very High Very High Very High
Lung Cancer 54 85.84 High High
Non-small-cell Lung Cancer 24 84.36 Quite High
Death 2 72.24 Quite High
Stress 8 66.44 Quite High
Targeted Disruption 1 56.56 Quite High
Adenocarcinoma 7 33.40 Quite Low
Malignant Neoplastic Disease 4 5.00 Very Low Very Low Very Low
Nicotine Addiction 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the wild-type KEAP1 in H838 cells stably expressing an ARE reporter completely abolished ARE reporter activity, whereas overexpression of the KEAP1 mutant construct did not, suggesting that the somatic mutations hamper the association between KEAP1 and NRF2 and consequently activate NRF2.
Negative_regulation (abolished) of Gene_expression (Expression) of wild-type
1) Confidence 0.02 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.86 Pain Relevance 0

General Comments

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