INT197558

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFE2L2) plasma membrane (NFE2L2) nucleus (NFE2L2)
DNA binding (NFE2L2) cytoplasm (NFE2L2)
NFE2L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 104 99.84 Very High Very High Very High
Stress 15 93.28 High High
Lung Cancer 54 85.08 High High
Non-small-cell Lung Cancer 24 68.40 Quite High
Malignant Neoplastic Disease 4 50.48 Quite High
Targeted Disruption 2 42.72 Quite Low
Adenocarcinoma 9 5.00 Very Low Very Low Very Low
Bone Disease 3 5.00 Very Low Very Low Very Low
Nicotine Addiction 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, more intensive studies are needed to unravel the mechanisms responsible for exaggerated NRF2 response in cancer cells even in the presence of wild-type KEAP1.
Regulation (responsible) of Gene_expression (response) of NRF2 associated with cancer
1) Confidence 0.37 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 1.05 Pain Relevance 0
Furthermore, RNA interference (RNAi) depletion of SQSTM1 resulted in an increase in the protein level of Keap1 and a concomitant decrease in the protein level of Nrf2 in the absence of changes in Keap1 or Nrf2 mRNA levels.
Regulation (changes) of Gene_expression (levels) of Nrf2 mRNA
2) Confidence 0.24 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0

General Comments

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