INT197560

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.12
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (KEAP1) nucleolus (KEAP1) nucleus (KEAP1)
cytoplasm (KEAP1)
Anatomy Link Frequency
lung 2
KEAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 24.32 Low Low
palliative 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 218 98.96 Very High Very High Very High
Cancer 424 95.28 Very High Very High Very High
Hyperplasia 4 87.28 High High
Cleidocranial Dysplasia 4 86.24 High High
Carcinoma In Situ 4 85.04 High High
Non-small-cell Lung Cancer 96 84.36 Quite High
Death 26 83.64 Quite High
Carcinoma 4 80.80 Quite High
Toxicity 15 67.52 Quite High
Stress 34 66.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, inhibition of KEAP1 expression by siRNA induced the expression of NRF2-driven genes in BEAS2B cells (Figure 6C).


Negative_regulation (inhibition) of Gene_expression (expression) of KEAP1
1) Confidence 0.58 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.47 Pain Relevance 0
Detection of KEAP1 alterations in early stages of lung tumor development (stage IB, Table S1) further suggests that loss of KEAP1 function may be an early event in lung cancer pathogenesis.
Negative_regulation (loss) of Gene_expression (function) of KEAP1 in lung associated with lung cancer
2) Confidence 0.43 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 1.34 Pain Relevance 0
Two pairs of fluorescently labeled microsatellite primers flanking KEAP1 (KEAP-UM1 [CA17], present upstream of the KEAP1 locus, and KEAP-DM1 [CA21], present downstream of the KEAP1 locus) were designed using Primer3 software and synthesized by Integrated DNA Technologies.
Negative_regulation (downstream) of Gene_expression (locus) of KEAP1
3) Confidence 0.43 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.22 Pain Relevance 0
Expression of the wild-type KEAP1 in H838 cells stably expressing an ARE reporter completely abolished ARE reporter activity, whereas overexpression of the KEAP1 mutant construct did not, suggesting that the somatic mutations hamper the association between KEAP1 and NRF2 and consequently activate NRF2.
Negative_regulation (abolished) of Gene_expression (Expression) of KEAP1
4) Confidence 0.43 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.86 Pain Relevance 0
M, Nrf2 protein levels decreased in a dose-dependent manner, whereas the expression of Keap1 and ?
Negative_regulation (whereas) of Gene_expression (expression) of Keap1
5) Confidence 0.28 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.23 Pain Relevance 0

General Comments

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