INT197561

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.19
Pain Relevance 0.42

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cell differentiation (ANGPTL4) signal transduction (ANGPTL4) extracellular space (ANGPTL4)
small molecule metabolic process (ANGPTL4) extracellular region (ANGPTL4) proteinaceous extracellular matrix (ANGPTL4)
Anatomy Link Frequency
liver 2
A549 1
NL20 1
H460 1
ANGPTL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 93 98.56 Very High Very High Very High
Inflammation 35 5.00 Very Low Very Low Very Low
Bile 20 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Endocannabinoid 4 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 30 100.00 Very High Very High Very High
Fatty Liver 7 89.92 High High
Obesity 71 86.80 High High
Body Weight 1 83.08 Quite High
Diabetes Mellitus 24 67.76 Quite High
Cancer 317 5.00 Very Low Very Low Very Low
Lung Cancer 163 5.00 Very Low Very Low Very Low
Non-small-cell Lung Cancer 72 5.00 Very Low Very Low Very Low
INFLAMMATION 42 5.00 Very Low Very Low Very Low
Stress 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPL activity is mostly regulated posttranslationally via altered secretion from liver of LPL-modulating factors, including apolipoprotein C-III (Apoc3), apolipoprotein A-V (Apoa5), Angiopoietin-like protein 3 (Angptl3), and Angiopoietin-like protein 4 (Angptl4).
Localization (secretion) of Angiopoietin-like protein 4 in liver associated with disorder of lipid metabolism
1) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.37 Pain Relevance 0.21
LPL activity is mostly regulated posttranslationally via altered secretion from liver of LPL-modulating factors, including apolipoprotein C-III (Apoc3), apolipoprotein A-V (Apoa5), Angiopoietin-like protein 3 (Angptl3), and Angiopoietin-like protein 4 (Angptl4).
Localization (secretion) of Angptl4 in liver associated with disorder of lipid metabolism
2) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.37 Pain Relevance 0.21
Noticeable increase was observed in Cd36, glucokinase (Gk), malic enzyme (Me), low-density lipoprotein (Ldl), microsomal transfer protein (Mtp), and angiopoietin-like 4 (Angptl4) in the absence of any change in CCAAT/enhancer binding protein alpha (C/ebp?)
Spec (observed) Localization (observed) of angiopoietin-like 4
3) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.46 Pain Relevance 0
HBE4, NL20, A549, H460, H1435, H292, H23, H358, H1299, H1993, H1395, and H838 cells were purchased from American Type Culture Collection (Manassas, Virginia, United States) and cultured under recommended conditions.
Localization (cultured) of NL20 in H460
4) Confidence 0.00 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0 Pain Relevance 0
HBE4, NL20, A549, H460, H1435, H292, H23, H358, H1299, H1993, H1395, and H838 cells were purchased from American Type Culture Collection (Manassas, Virginia, United States) and cultured under recommended conditions.
Localization (cultured) of NL20 in A549
5) Confidence 0.00 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0 Pain Relevance 0
HBE4, NL20, A549, H460, H1435, H292, H23, H358, H1299, H1993, H1395, and H838 cells were purchased from American Type Culture Collection (Manassas, Virginia, United States) and cultured under recommended conditions.
Localization (cultured) of NL20 in NL20
6) Confidence 0.00 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0 Pain Relevance 0

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