INT197565

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.47
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GCLM) small molecule metabolic process (GCLM) cellular nitrogen compound metabolic process (GCLM)
GCLM (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 6 100.00 Very High Very High Very High
Central nervous system 1 72.36 Quite High
Inflammation 5 38.56 Quite Low
Potency 13 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autism 148 98.80 Very High Very High Very High
Cancer 114 95.12 Very High Very High Very High
Drug Induced Neurotoxicity 2 94.28 High High
Hepatocellular Cancer 4 69.96 Quite High
Autoimmune Disease 1 65.92 Quite High
Repression 1 62.76 Quite High
Stress 16 61.04 Quite High
Malignant Neoplastic Disease 4 59.48 Quite High
Apoptosis 23 58.00 Quite High
Toxicity 185 57.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed a negative correlation between GCLM and Hg levels in TD, but no correlation in AU.
Gene_expression (levels) of GCLM associated with autism
1) Confidence 0.25 Published 2009 Journal Neurotox Res Section Body Doc Link PMC3006666 Disease Relevance 0.68 Pain Relevance 0.08
We measured the transcript levels of NRF2, NQO1, GSR, GCLc, GCLm, MRP1, and MRP2 by real-time RT-PCR.
Gene_expression (levels) of GCLm
2) Confidence 0.24 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.60 Pain Relevance 0
The enzymes involved in the synthesis of GSH (glutamate-cysteine ligase and GSH synthetase) are also present and can be up regulated by exogenous chemicals [15].
Gene_expression (synthesis) of glutamate-cysteine ligase associated with glutamate
3) Confidence 0.02 Published 2010 Journal Combinatorial Chemistry & High Throughput Screening Section Body Doc Link PMC2908937 Disease Relevance 0.18 Pain Relevance 0.05

General Comments

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