INT197574

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (KEAP1) nucleolus (KEAP1) nucleus (KEAP1)
cytoplasm (KEAP1)
KEAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 104 91.32 High High
Carcinoma 1 88.24 High High
Carcinoma In Situ 1 86.44 High High
Cleidocranial Dysplasia 1 85.52 High High
Hyperplasia 1 85.08 High High
Lung Cancer 54 79.76 Quite High
Non-small-cell Lung Cancer 24 77.76 Quite High
Adenocarcinoma 7 60.64 Quite High
Nicotine Addiction 3 36.64 Quite Low
Stress 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding suggests that loss of both functional KEAP1 alleles is essential for constitutive activation of NRF2-mediated gene expression.
Positive_regulation (essential) of Negative_regulation (loss) of KEAP1
1) Confidence 0.50 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 1.15 Pain Relevance 0

General Comments

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