INT197576

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.10
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFE2L2) plasma membrane (NFE2L2) nucleus (NFE2L2)
DNA binding (NFE2L2) cytoplasm (NFE2L2)
Anatomy Link Frequency
lung 1
Loh1 (Mus musculus)
NFE2L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 54 99.16 Very High Very High Very High
Cancer 104 96.92 Very High Very High Very High
Malignant Neoplastic Disease 4 90.44 High High
Non-small-cell Lung Cancer 24 81.32 Quite High
Stress 8 72.16 Quite High
Targeted Disruption 1 6.40 Low Low
Adenocarcinoma 7 5.00 Very Low Very Low Very Low
Nicotine Addiction 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the number of tumors examined in this study is not sufficiently large to lead to a definitive conclusion, this study is the first to our knowledge to show that mutations and LOH in KEAP1, as well as possibly other non-mutation-based mechanisms, enable high NRF2 activity in primary lung tumors.
LOH Positive_regulation (enable) of NRF2 in lung associated with lung cancer and cancer
1) Confidence 0.49 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 1.10 Pain Relevance 0

General Comments

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