INT1976

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1977
Last Reported 2009
Negated 24
Speculated 10
Reported most in Abstract
Documents 80
Total Number 91
Disease Relevance 20.19
Pain Relevance 36.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
plasma 31
pituitary 12
lactotrope 4
platelets 2
nasal 2
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 184 100.00 Very High Very High Very High
narcan 144 100.00 Very High Very High Very High
Morphine 117 100.00 Very High Very High Very High
agonist 107 100.00 Very High Very High Very High
Dopamine 82 100.00 Very High Very High Very High
methadone 41 100.00 Very High Very High Very High
Opioid 40 100.00 Very High Very High Very High
opiate 32 100.00 Very High Very High Very High
anesthesia 22 100.00 Very High Very High Very High
Enkephalin 19 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 236 100.00 Very High Very High Very High
Reprotox - General 1 18 100.00 Very High Very High Very High
Headache 9 100.00 Very High Very High Very High
Sleep Disorders 4 100.00 Very High Very High Very High
Dizziness 3 100.00 Very High Very High Very High
Heart Rate Under Development 2 100.00 Very High Very High Very High
Back Pain 1 100.00 Very High Very High Very High
Sleep Initiation And Maintenance Disorders 1 100.00 Very High Very High Very High
Dyspnea 1 100.00 Very High Very High Very High
Prolactinoma 58 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of naloxone infusion on plasma prolactin (PRL) levels and on the PRL response to mechanical breast emptying were investigated in a group of puerperal women, Five, 10, and 20 mg naloxone administered to women on days 2 to 3 of the puerperium produced no significant change in serum PRL.
Spec (investigated) Regulation (effects) of Gene_expression (levels) of PRL in plasma associated with narcan
1) Confidence 0.62 Published 1983 Journal Fertil. Steril. Section Abstract Doc Link 6685061 Disease Relevance 0 Pain Relevance 0.24
In order to investigate the role of opioids in the regulation of PRL and GH gene expression in the rat pituitary, we studied the effects of chronic administration of the opioid drug morphine and an opiate receptor antagonist naloxone on both PRL and GH gene expression as measured by in situ hybridization.
Regulation (effects) of Gene_expression (expression) of PRL in pituitary associated with antagonist, narcan, opiate, opioid and morphine
2) Confidence 0.61 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680424 Disease Relevance 0 Pain Relevance 1.15
In order to investigate the role of opioids in the regulation of PRL and GH gene expression in the rat pituitary, we studied the effects of chronic administration of the opioid drug morphine and an opiate receptor antagonist naloxone on both PRL and GH gene expression as measured by in situ hybridization.
Spec (investigate) Regulation (role) of Gene_expression (expression) of PRL in pituitary associated with antagonist, narcan, opiate, opioid and morphine
3) Confidence 0.61 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680424 Disease Relevance 0 Pain Relevance 0.97
Dysregulation of prolactin synthesis and secretion may be the result of prolactin gene modulation.
Regulation (Dysregulation) of Gene_expression (synthesis) of prolactin
4) Confidence 0.60 Published 2000 Journal Biol Signals Recept Section Abstract Doc Link 10686432 Disease Relevance 0.97 Pain Relevance 0.22
Different neurotransmitters (Dopamine, serotonin, GABA...) and hormones (TRH, oestrogenes...) are involved in the central regulation of prolactin synthesis and release.
Regulation (regulation) of Gene_expression (synthesis) of prolactin associated with gaba, dopamine, neurotransmitter and serotonin
5) Confidence 0.48 Published 1987 Journal Encephale Section Abstract Doc Link 3297633 Disease Relevance 0.31 Pain Relevance 0.32
Intravenous injection of 5 mg/kg morphine did not change plasma PRL levels in the sham-operated lactating rats, but it resulted in a significant increase of plasma PRL levels in ADX lactating animals, with or without corticosterone replacement.
Neg (not) Regulation (change) of Gene_expression (levels) of PRL in plasma associated with morphine
6) Confidence 0.45 Published 1991 Journal Brain Res. Section Abstract Doc Link 1786530 Disease Relevance 0.09 Pain Relevance 0.65
Morphine sulphate reversed the effect of dopamine on prolactin secretion and on the proportion of prolactin in the gland that was in the dimeric form.
Regulation (effect) of Gene_expression (proportion) of prolactin in gland associated with dopamine and morphine
7) Confidence 0.45 Published 1984 Journal Biosci. Rep. Section Abstract Doc Link 6713084 Disease Relevance 0 Pain Relevance 0.24
The difference in the stimulation-evoked release occurred in the presence of similar circulating serum PRL levels in the two groups as a result of the 3-day E2 treatment.
Regulation (circulating) of Gene_expression (levels) of PRL
8) Confidence 0.45 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3796794 Disease Relevance 0 Pain Relevance 0.20
The difference in the stimulation-evoked release occurred in the presence of similar circulating serum PRL levels in the two groups as a result of the 3-day E2 treatment.
Regulation (occurred) of Gene_expression (levels) of PRL
9) Confidence 0.45 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3796794 Disease Relevance 0 Pain Relevance 0.20
N-Nitro-L-arginine methyl ester (25 mg/kg i.p.) decreased cold-stimulated (rats were kept 30 min at +4 degrees C) TSH levels but did not alter basal TSH, GH or prolactin levels.
Neg (not) Regulation (alter) of Gene_expression (levels) of prolactin
10) Confidence 0.45 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7957594 Disease Relevance 0 Pain Relevance 0.72
Assay of circulating peripheral beta-endorphins could indicate that the face cooling-induced PRL blunted response does not necessarily involve an opioid mediation.
Neg (not) Regulation (involve) of Gene_expression (response) of PRL in face associated with opioid
11) Confidence 0.45 Published 1989 Journal Eur J Appl Physiol Occup Physiol Section Abstract Doc Link 2527748 Disease Relevance 0.14 Pain Relevance 0.14
The effects of handling and ether stress on serum prolactin (PRL) levels in gonadally active and gonadally regressed male golden hamsters and in females in different stages of the estrous cycle were examined.
Spec (examined) Regulation (effects) of Gene_expression (levels) of serum prolactin associated with stress
12) Confidence 0.45 Published 1983 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 6889312 Disease Relevance 0.10 Pain Relevance 0.07
The effects of naloxone infusion on plasma prolactin (PRL) levels and on the PRL response to mechanical breast emptying were investigated in a group of puerperal women, Five, 10, and 20 mg naloxone administered to women on days 2 to 3 of the puerperium produced no significant change in serum PRL.
Spec (investigated) Regulation (effects) of Gene_expression (levels) of prolactin in plasma associated with narcan
13) Confidence 0.45 Published 1983 Journal Fertil. Steril. Section Abstract Doc Link 6685061 Disease Relevance 0 Pain Relevance 0.24
The effects of handling and ether stress on serum prolactin (PRL) levels in gonadally active and gonadally regressed male golden hamsters and in females in different stages of the estrous cycle were examined.
Spec (examined) Regulation (effects) of Gene_expression (levels) of PRL associated with stress
14) Confidence 0.45 Published 1983 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 6889312 Disease Relevance 0.10 Pain Relevance 0.07
For several months of post-treatment period (average 6.75 months), we monitored the time-course changes in PRL and T levels in all monkeys for 10 hours after a single injection of morphine at the same dose given during the treatment period.
Regulation (changes) of Gene_expression (levels) of PRL associated with morphine
15) Confidence 0.45 Published 1998 Journal J. Med. Primatol. Section Abstract Doc Link 9606036 Disease Relevance 0.23 Pain Relevance 0.53
The results of a study of effects of stress on serum prolactin (PRL) levels in patients with SLE reveal statistically significant differences in serum PRL level readings in samples taken over a short period of time, thus corroborating the need to take into account PRL stress induction during sample withdrawals and to interpret the values obtained, especially where moderate idiopathic hyperprolactinemia was detected.
Regulation (effects) of Gene_expression (levels) of PRL associated with galactorrhea, stress and systemic lupus erythematosus
16) Confidence 0.45 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114279 Disease Relevance 0.53 Pain Relevance 0
The results of a study of effects of stress on serum prolactin (PRL) levels in patients with SLE reveal statistically significant differences in serum PRL level readings in samples taken over a short period of time, thus corroborating the need to take into account PRL stress induction during sample withdrawals and to interpret the values obtained, especially where moderate idiopathic hyperprolactinemia was detected.
Regulation (effects) of Gene_expression (levels) of prolactin associated with galactorrhea, stress and systemic lupus erythematosus
17) Confidence 0.45 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114279 Disease Relevance 0.53 Pain Relevance 0
In the present study, serum PRL was minimally elevated in 16 of 116 colon cancer patients and 2 of 25 control subjects; medications or chemotherapy appeared to be responsible for the PRL elevations in 11 of 16 cancer patients.
Regulation (responsible) of Gene_expression (elevations) of PRL in colon associated with cancer and colon cancer
18) Confidence 0.45 Published 2000 Journal Cancer Invest. Section Abstract Doc Link 10705875 Disease Relevance 0.94 Pain Relevance 0.06
Effects of morphine and naloxone on prolactin and growth hormone gene expression in the male rat pituitary gland.
Regulation (Effects) of Gene_expression (expression) of prolactin in pituitary gland associated with narcan and morphine
19) Confidence 0.45 Published 1993 Journal J. Neuroendocrinol. Section Title Doc Link 8680424 Disease Relevance 0 Pain Relevance 1.26
Both drugs were equally effective in lowering PRL levels in both trials.
Regulation (effective) of Gene_expression (levels) of PRL
20) Confidence 0.45 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1997518 Disease Relevance 0.82 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox