INT197627

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.16
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1) DNA binding (RB1) nucleus (RB1)
molecular_function (RB1) cell division (RB1) cellular_component (RB1)
RB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 73.96 Quite High
imagery 14 5.00 Very Low Very Low Very Low
cryotherapy 5 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
vincristine 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
pruritus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 194 100.00 Very High Very High Very High
Retinoblastoma 82 99.88 Very High Very High Very High
Papillomavirus Infection 55 98.74 Very High Very High Very High
Disease 31 97.80 Very High Very High Very High
Basal And Squamous Cell Skin Cancer 71 97.08 Very High Very High Very High
Breast Cancer 124 95.36 Very High Very High Very High
Infection 13 90.64 High High
Targeted Disruption 8 89.12 High High
Syndrome 5 77.64 Quite High
Inflammatory Breast Neoplasms 3 74.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss or mutations of both alleles of the retinoblastoma gene RB1, localized to chromosome 13q1.4 [4], are required to develop the disease.
Localization (localized) of RB1 associated with disease and retinoblastoma
1) Confidence 0.69 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1586012 Disease Relevance 1.56 Pain Relevance 0
Among molecules regulating the p53 and RB tumor suppressor pathways, mutation of p53, overexpression of cyclin D1b, LMW cyclin E are apparently associated with poor clinical outcome of patients.
Localization (mutation) of RB associated with cancer
2) Confidence 0.25 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.24 Pain Relevance 0.13
The HPV viral gene products E6 and E7 interact with host cell p53 and Rb proteins, resulting in p53 dysfunction and inactivation of Rb, respectively.
Localization (resulting) of Rb associated with papillomavirus infection
3) Confidence 0.05 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3003991 Disease Relevance 1.37 Pain Relevance 0

General Comments

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