INT19763

Context Info Confidence 0.78 First Reported 1990 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 69 Total Number 76 Disease Relevance 32.92 Pain Relevance 18.87

Anatomy Link Frequency wrists 5 median nerve 4 shells 3 nerve 3 tendon 2 CTs (Homo sapiens)

Pain Link Frequency Relevance Heat carpal tunnel syndrome 934 100.00 imagery 65 99.76 complementary and alternative medicine 278 98.32 Sciatica 28 96.04 Pain 124 90.88 Demyelination 5 90.88 Facet joint 2 89.84 peripheral neuropathy 1 89.28 Paresthesia 23 86.88 Arthritis 12 84.28

Disease Link Frequency Relevance Heat Carpal Tunnel Syndrome 1123 100.00 Demyelinating Disease 6 100.00 Renal Failure 13 99.20 Lipoma 2 99.16 Injury 44 99.14 Median Neuropathy 5 99.08 Synovitis 6 99.00 Hypertrophy 15 98.96 Hemangioma 2 98.80 Obesity 25 98.50

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, he argued that occupational trauma is seldom the precipitating factor in the production of CTS15.

Gene_expression (production) of CTS15 associated with injury

1) Confidence 0.78 Published 2008 Journal Ulster Med J Section Body Doc Link PMC2397020 Disease Relevance 1.34 Pain Relevance 1.11

CONCLUSION: The authors suggest that there may not be any association between CTS and ulnar nerve compression at the wrist.

Gene_expression (compression) of CTS in wrist

2) Confidence 0.59 Published 2009 Journal Clin Neurol Neurosurg Section Body Doc Link 19084328 Disease Relevance 0.11 Pain Relevance 0

NCS not only allow a diagnosis of CTS but also help in the diagnosis of other conditions presenting with similar symptoms e.g. cervical radiculopathy, polyneuropathy, other median nerve entrapment syndromes74,88–90.

Gene_expression (diagnosis) of CTS in median nerve associated with neuropathy, nerve root compression, sciatica and carpal tunnel syndrome

3) Confidence 0.59 Published 2008 Journal Ulster Med J Section Body Doc Link PMC2397020 Disease Relevance 0.97 Pain Relevance 0.61

BMI, wrist ratio and shape index were found to be independent risk factors of CTS development in all patients and females.

Gene_expression (development) of CTS in wrist associated with obesity and carpal tunnel syndrome

4) Confidence 0.58 Published 2008 Journal Folia Morphol. (Warsz) Section Abstract Doc Link 18335412 Disease Relevance 1.40 Pain Relevance 0.85

A total of 131 patients with clinical symptoms of CTS and 131 normal subjects were enrolled, of whom 121 were female both in the CTS cases and the controls.

Gene_expression (cases) of CTS associated with carpal tunnel syndrome

5) Confidence 0.58 Published 2008 Journal Folia Morphol. (Warsz) Section Abstract Doc Link 18335412 Disease Relevance 1.15 Pain Relevance 0.69

The first description of median nerve compression in the carpal tunnel goes back to 1854, but it was only a century later that the term "carpal tunnel syndrome" (CTS) appeared in print.

Gene_expression (appeared) of carpal tunnel syndrome in median nerve associated with carpal tunnel syndrome

6) Confidence 0.58 Published 2008 Journal Chir Organi Mov Section Abstract Doc Link 18566759 Disease Relevance 0.45 Pain Relevance 0.17

The first description of median nerve compression in the carpal tunnel goes back to 1854, but it was only a century later that the term "carpal tunnel syndrome" (CTS) appeared in print.

Gene_expression (appeared) of CTS in median nerve associated with carpal tunnel syndrome

7) Confidence 0.58 Published 2008 Journal Chir Organi Mov Section Abstract Doc Link 18566759 Disease Relevance 0.45 Pain Relevance 0.17

50 weeks versus > 50 weeks, non-dominant versus dominant side affected, unilateral versus bilateral CTS complaints, no previous episodes versus previous episodes of CTS complaints, preference for surgery versus splinting versus no preference, baseline severity of the main complaint ?

Gene_expression (complaints) of CTS

8) Confidence 0.58 Published 2001 Journal BMC Neurol Section Body Doc Link PMC64540 Disease Relevance 0 Pain Relevance 0.03

Nerve conduction studies were compatible with a diagnosis of CTS in 136 patients (CTS group).

Gene_expression (group) of CTS in Nerve

9) Confidence 0.58 Published 2004 Journal J Clin Rheumatol Section Body Doc Link 17043482 Disease Relevance 0.18 Pain Relevance 0

Of all wrists of PD patients, 13 (24.4%) have been diagnosed as CTS and 7 (19.4%) control wrists had CTS.

Gene_expression (control) of CTS in wrists

10) Confidence 0.58 Published 2008 Journal Eur J Radiol Section Body Doc Link 17855036 Disease Relevance 0 Pain Relevance 0

Of all wrists of PD patients, 13 (24.4%) have been diagnosed as CTS and 7 (19.4%) control wrists had CTS.

Gene_expression (control) of CTS in wrists

11) Confidence 0.58 Published 2008 Journal Eur J Radiol Section Body Doc Link 17855036 Disease Relevance 0 Pain Relevance 0

Among study physician diagnosed cases, 64% were CTS negative in 2001, 76% were negative in 2004, 13% were positive in both years, 22% became negative after being positive, and 11% became positive after being negative.

Neg (negative) Gene_expression (negative) of CTS

12) Confidence 0.58 Published 2008 Journal Int Arch Occup Environ Health Section Body Doc Link 17909837 Disease Relevance 0 Pain Relevance 0

CONCLUSIONS: In our study, among a group of heavy labourers, no cases of CTS were detected.

Gene_expression (detected) of CTS

13) Confidence 0.58 Published 2008 Journal Occup Med (Lond) Section Body Doc Link 18211908 Disease Relevance 0.07 Pain Relevance 0

By setting criteria of electrophysiological tests, 179 hands in 113 patients were classified into mild, moderate and severe degrees of CTS.

Gene_expression (degrees) of CTS associated with carpal tunnel syndrome

14) Confidence 0.58 Published 2008 Journal The Journal of hand surgery, European volume Section Abstract Doc Link 18332017 Disease Relevance 0.80 Pain Relevance 0.85

METHODS: A decision-making and economic evaluation model was made to compare three strategies: option A (EP Studies for all patients with suspected CTS), option B (prior selection by neurologist and EP studies only if axonal CTS was suspected) and option C (prior selection by neurologist and EP studies only if CTS, axonal or otherwise was suspected).

Gene_expression (selection) of CTS

15) Confidence 0.58 Published 2008 Journal Neurologia Section Body Doc Link 18726719 Disease Relevance 0.09 Pain Relevance 0

Significant changes in ulnar nerve conduction were present even in the early stages of CTS.

Gene_expression (present) of CTS in ulnar nerve associated with carpal tunnel syndrome

16) Confidence 0.58 Published 2008 Journal Muscle Nerve Section Abstract Doc Link 18671289 Disease Relevance 1.34 Pain Relevance 0.94

The WFR in patients presenting with CTS was 2.1+/-0.5.

Gene_expression (presenting) of CTS

17) Confidence 0.58 Published 2008 Journal Clin Neurophysiol Section Body Doc Link 18387336 Disease Relevance 0.09 Pain Relevance 0

METHODS: Reports from 3 sources were evaluated with regard to support for etiological theories of CTS: 1) patient-oriented information on CTS from the Internet, 2) recent physician-oriented information on CTS from medical journals indexed on Index Medicus, and 3) articles addressing the etiology of CTS from the 1997 National Institute for Occupational Safety and Health report.

Gene_expression (theories) of CTS

18) Confidence 0.58 Published 2008 Journal J Hand Surg Am Section Body Doc Link 18762100 Disease Relevance 0.10 Pain Relevance 0

CONCLUSIONS: There are notable disparities between popular (Internet) and scientific (Index Medicus) theories of CTS causation.

Gene_expression (causation) of CTS

19) Confidence 0.58 Published 2008 Journal J Hand Surg Am Section Body Doc Link 18762100 Disease Relevance 0.06 Pain Relevance 0

Severity of CTS multidimensionally assessed was significantly greater in patients with a history of dropped objects than those without.

Gene_expression (Severity) of CTS associated with carpal tunnel syndrome

20) Confidence 0.58 Published 2010 Journal Neurol. Sci. Section Abstract Doc Link 20217442 Disease Relevance 0.51 Pain Relevance 0.66

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