INT197662

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.54
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SHBG)
Anatomy Link Frequency
tunica albuginea 2
SHBG (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 2 98.96 Very High Very High Very High
headache 18 94.32 High High
tolerance 4 84.32 Quite High
noradrenaline 12 79.24 Quite High
carbamazepine 17 72.16 Quite High
transdermal 9 59.52 Quite High
Pain 3 59.12 Quite High
imagery 5 51.60 Quite High
antiepileptic Drug 1 50.00 Quite Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 18 94.32 High High
Reprotox - General 2 66 93.84 High High
Diabetes Mellitus 29 93.12 High High
Polycystic Ovary Syndrome 83 91.36 High High
Obesity 44 89.76 High High
Aging 7 89.36 High High
Frailty 4 88.56 High High
Weight Loss 7 88.40 High High
Hypoactive Sexual Desire Disorder 76 88.00 High High
Reprotox - General 1 9 86.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tibolone lowers sex hormone-binding globulin (SHBG) and increases circulating free testosterone, adding to its androgenicity.
Negative_regulation (lowers) of Positive_regulation (increases) of SHBG
1) Confidence 0.39 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971736 Disease Relevance 0.68 Pain Relevance 0.03
Loss of significant weight has been reported to result in spontaneous resumption of ovulation (Crosignani et al 2003), improvement in fertility (Norman et al 2004), increased SHBG, and reduced basal level of insulin (Huber-Buchholz et al 1999; Tolino et al 2005).
Negative_regulation (reduced) of Positive_regulation (increased) of SHBG
2) Confidence 0.35 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.59 Pain Relevance 0.04
In addition, AEDs can decrease the availability of androgen substrates for aromatase pathway by increasing the catabolism of sex steroids and increasing SHBG levels, resulting in reduced free testosterone and DHEA levels [61-64].
Negative_regulation (decrease) of Positive_regulation (increasing) of SHBG
3) Confidence 0.30 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1586194 Disease Relevance 0.22 Pain Relevance 0.04
Systemic changes and alterations in the structure and function of the penis in elderly men include hormonal changes (mainly testosterone decrease and increase in sex hormone binding globulin that resulting decreased bioavailability of testosterone) (Margolese 2000), decrease in elastic fibers and increase in collagen fibers in the tunica albuginea (Akkus et al 1997) and molecular changes (decrease in nitric oxide synthase) (Andrew and Mayer 1999).
Negative_regulation (decrease) of Positive_regulation (increase) of sex hormone binding globulin in tunica albuginea associated with bioavailability
4) Confidence 0.22 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699643 Disease Relevance 0.40 Pain Relevance 0.05
At 1 week after the start of cilnidipine therapy, a second MDT was performed, and the maximum increase in SBP was limited to 27 mmHg.
Negative_regulation (limited) of Positive_regulation (increase) of SBP
5) Confidence 0.10 Published 2007 Journal Biopsychosoc Med Section Body Doc Link PMC2045659 Disease Relevance 0.57 Pain Relevance 0.37

General Comments

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