INT197676

Context Info Confidence 0.06 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.10 Pain Relevance 0

enzyme binding (ESR1, Pgr) cytoplasm (ESR1, Pgr) nucleus (ESR1, Pgr) nucleoplasm (ESR1) DNA binding (ESR1) protein complex (ESR1)

Anatomy Link Frequency epithelium 4 ESR1 (Homo sapiens) Pgr (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 6 8.56 Pain 6 5.00 ketamine 2 5.00 Kinase C 2 5.00 endometriosis 2 5.00

Disease Link Frequency Relevance Heat Breast Cancer 22 51.12 Frailty 6 43.96 Reprotox - General 2 10 5.00 Endometriosis (extended) 10 5.00 Pain 6 5.00 Cancer 6 5.00 Reprotox - General 1 4 5.00 Sprains And Strains 2 5.00 Body Weight 2 5.00 Reprotox - General 3 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Also, since ER regulates synthesis of the progesterone receptor (PR), it is possible that antagonism of ER by tamoxifen results in PR downregulation and that PR may be involved in exocytosis of glycogen from the vaginal epithelium.

ER Regulation (regulates) of Gene_expression (synthesis) of progesterone receptor in epithelium

1) Confidence 0.06 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0.05 Pain Relevance 0

Also, since ER regulates synthesis of the progesterone receptor (PR), it is possible that antagonism of ER by tamoxifen results in PR downregulation and that PR may be involved in exocytosis of glycogen from the vaginal epithelium.

ER Regulation (regulates) of Gene_expression (synthesis) of PR in epithelium

2) Confidence 0.04 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0.05 Pain Relevance 0

General Comments

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