INT19768

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Context Info
Confidence 0.57
First Reported 1989
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 10.54
Pain Relevance 5.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LAMC2) extracellular region (LAMC2) cell adhesion (LAMC2)
Anatomy Link Frequency
CSF 5
blood 1
plasma 1
LAMC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Endogenous opioid 4 100.00 Very High Very High Very High
diabetic neuropathy 4 99.84 Very High Very High Very High
Lasting pain 6 99.28 Very High Very High Very High
Enkephalin 8 98.64 Very High Very High Very High
cva 16 98.52 Very High Very High Very High
unmyelinated 1 98.44 Very High Very High Very High
intrathecal 2 97.84 Very High Very High Very High
Pain 17 97.60 Very High Very High Very High
Neuropathic pain 4 97.20 Very High Very High Very High
headache 7 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 6 100.00 Very High Very High Very High
Diabetic Neuropathy 4 99.84 Very High Very High Very High
Parkinson's Disease 1 99.84 Very High Very High Very High
Cyst 5 99.36 Very High Very High Very High
Pain 16 99.28 Very High Very High Very High
Pathologic Constriction 5 99.20 Very High Very High Very High
Epstein-barr Virus 9 99.08 Very High Very High Very High
Motor Neuron Diseases 7 99.00 Very High Very High Very High
Cv General 3 Under Development 5 98.52 Very High Very High Very High
Cytomegalovirus Infection 3 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is ample evidence indicating diminished endogenous opioid CSF/plasma levels in chronic pain patients, yet little is known about the functional effects of these opioid changes.
Negative_regulation (diminished) of CSF in plasma associated with lasting pain, endogenous opioid and opioid
1) Confidence 0.57 Published 1999 Journal Neurosci Biobehav Rev Section Abstract Doc Link 10541062 Disease Relevance 0.93 Pain Relevance 1.45
In conclusion, the CSF TAC was strongly correlated with serum TAC, and a decrease in CSF TAC was demonstrated in MND patients compared to controls that was not independent from serum antioxidants, this translating in a systemic (but prevailing in the CNS) oxidative damage in this pathology.
Negative_regulation (decrease) of CSF in CSF associated with motor neuron diseases
2) Confidence 0.57 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16600498 Disease Relevance 0.98 Pain Relevance 0.16
Furthermore, the CSF/blood glucose ratio was decreased (0.14), which was rarely described.
Negative_regulation (decreased) of CSF in blood
3) Confidence 0.57 Published 2008 Journal Arch Pediatr Section Abstract Doc Link 18155890 Disease Relevance 0.71 Pain Relevance 0.19
The levels of HVA and MHPG in CSF were decreased.
Negative_regulation (decreased) of CSF
4) Confidence 0.42 Published 1989 Journal Rinsho Shinkeigaku Section Abstract Doc Link 2557996 Disease Relevance 1.40 Pain Relevance 0.36
It is confirmed that there is a reduction of HVA in CSF in Parkinsonian patients.
Negative_regulation (reduction) of CSF in CSF associated with parkinson's disease
5) Confidence 0.42 Published 1989 Journal Zhonghua Shen Jing Jing Shen Ke Za Zhi Section Abstract Doc Link 2791764 Disease Relevance 0.44 Pain Relevance 0.70
In CSF, beta-ELI levels decreased at the third sample (p less than 0.01 when compared to the painful levels) and at the end of surgery (p less than 0.01, p less than 0.01 and p less than 0.05 vs first, second and third samples, respectively).
Negative_regulation (decreased) of CSF in CSF associated with pain
6) Confidence 0.41 Published 1990 Journal J Neurosurg Sci Section Abstract Doc Link 2092099 Disease Relevance 0.08 Pain Relevance 0.48
However, the assumption that venous stenosis leads to a high pressure gradient that decreases CSF resorption through arachnoid villi requires further evidence.
Negative_regulation (decreases) of CSF associated with pathologic constriction
7) Confidence 0.41 Published 2009 Journal Neurosurg Focus Section Abstract Doc Link 19877792 Disease Relevance 1.43 Pain Relevance 0.48
Therefore, it is not unreasonable to suppose that the sacral cyst appeared to be responsible for development of CSFH in the patient.
Negative_regulation (development) of CSF associated with pressure volume 2 under development and cyst
8) Confidence 0.41 Published 2008 Journal Masui Section Abstract Doc Link 18975542 Disease Relevance 0.65 Pain Relevance 0.03
Finally, there were reduced serum/CSF ratios of antibody to EBV, but not to total IgG or albumin, consistent with intrathecal antibody synthesis.
Neg (not) Negative_regulation (reduced) of CSF associated with epstein-barr virus and intrathecal
9) Confidence 0.41 Published 2002 Journal Brain Section Abstract Doc Link 11834601 Disease Relevance 1.82 Pain Relevance 0.23
We conclude that CSF beta-EP levels appear to be reduced in diabetic polyneuropathy but they do not relate to the presence of neuropathic pain.
Negative_regulation (reduced) of CSF in CSF associated with diabetic neuropathy and neuropathic pain
10) Confidence 0.41 Published 1995 Journal J. Diabetes Complicat. Section Abstract Doc Link 7599354 Disease Relevance 1.19 Pain Relevance 0.92
Impaired CSF circulation can result in increased intracranial pressure, causing hydrocephalus, severe headaches, tinnitus, diplopia, and transient visual obscurations.
Negative_regulation (Impaired) of CSF in CSF associated with tinnitus, diplopia, hydrocephalus, headache and cva
11) Confidence 0.21 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.91 Pain Relevance 0.32

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