INT1977

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 6
Speculated 2
Reported most in Abstract
Documents 98
Total Number 100
Disease Relevance 17.06
Pain Relevance 47.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
plasma 32
pituitary 10
face 6
blood 4
body 4
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 162 100.00 Very High Very High Very High
Dopamine 67 100.00 Very High Very High Very High
agonist 60 100.00 Very High Very High Very High
opiate 55 100.00 Very High Very High Very High
Dynorphin 27 100.00 Very High Very High Very High
methadone 24 100.00 Very High Very High Very High
anesthesia 23 100.00 Very High Very High Very High
dexamethasone 20 100.00 Very High Very High Very High
Buprenorphine 14 100.00 Very High Very High Very High
epidural 8 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 162 100.00 Very High Very High Very High
Pain 7 100.00 Very High Very High Very High
Hypothermia 5 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 3 100.00 Very High Very High Very High
Cushing's Syndrome /

Hypercortisolism

1 99.88 Very High Very High Very High
Decapitation 18 99.20 Very High Very High Very High
Heart Rate Under Development 3 98.94 Very High Very High Very High
Body Weight 5 98.60 Very High Very High Very High
Cluster Headache 7 98.32 Very High Very High Very High
Cancer Pain 3 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma PRL increase induced by clonidine or xylazine was suppressed by intravenous injection of naloxone (125 micrograms/100 g of body wt), an opiate antagonist.
Negative_regulation (suppressed) of Positive_regulation (increase) of PRL in body associated with antagonist, narcan, opiate and clonidine
1) Confidence 0.59 Published 1989 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2813439 Disease Relevance 0 Pain Relevance 0.72
Naloxone administration did not decrease previously increased mean serum levels of prolactin in pituitary-grafted rats.
Neg (not) Negative_regulation (decrease) of Positive_regulation (increased) of prolactin in pituitary associated with narcan
2) Confidence 0.59 Published 1994 Journal Vet Hum Toxicol Section Abstract Doc Link 7900271 Disease Relevance 0.07 Pain Relevance 0.72
The serum prolactin increase induced by naloxone at 1900 h was prevented by the s.c. administration of 5 mg progesterone given 7 h earlier.
Negative_regulation (prevented) of Positive_regulation (increase) of prolactin associated with narcan
3) Confidence 0.59 Published 1994 Journal J. Endocrinol. Section Abstract Doc Link 8138757 Disease Relevance 0 Pain Relevance 0.52
Training the animals to be handled prevented the increase in plasma prolactin levels produced by decapitation; training had no influence on the decapitation-induced rises in plasma CA concentrations.
Negative_regulation (prevented) of Positive_regulation (increase) of prolactin in plasma associated with catecholamine and decapitation
4) Confidence 0.59 Published 1981 Journal J Pharmacol Methods Section Abstract Doc Link 7311568 Disease Relevance 0.20 Pain Relevance 0.36
Pretreatment with the 5-HT3 receptor antagonists ICS 205-930 or GR 38032F (0.05-2.5 mg/kg i.p.) inhibited the PRL response induced by 5-HT or by 5-HTP + fluoxetine.
Negative_regulation (inhibited) of Positive_regulation (induced) of PRL associated with antagonist and fluoxetine
5) Confidence 0.59 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1386914 Disease Relevance 0 Pain Relevance 0.70
The increase in plasma prolactin observed in sham-operated and fornix groups was completely abolished in amygdala-cut animals.
Negative_regulation (abolished) of Positive_regulation (increase) of prolactin in fornix associated with amygdala
6) Confidence 0.59 Published 1975 Journal Endocrinology Section Abstract Doc Link 1098905 Disease Relevance 0.20 Pain Relevance 0.37
Nalmetrene blocked both the acute elevation of PRL and the increase in 5-HT turnover in the medial preoptic nucleus and ventromedial nucleus induced by EB.
Negative_regulation (blocked) of Positive_regulation (elevation) of PRL in medial preoptic nucleus
7) Confidence 0.59 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6328344 Disease Relevance 0.24 Pain Relevance 0.73
The increase of plasma prolactin levels induced by third-ventricle injection of histamine was blocked by intraventricular injection of ranitidine, an H2-antagonist, but not by systemic administration of mepyramine, an H1-antagonist.
Negative_regulation (blocked) of Positive_regulation (increase) of prolactin in ventricle associated with antagonist
8) Confidence 0.58 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6308490 Disease Relevance 0 Pain Relevance 0.19
However, monkeys treated with 3.0 and 6.0 mg/kg/day showed a decrease in T level and an increase in PRL level during the early post-treatment period.
Negative_regulation (decrease) of Positive_regulation (increase) of PRL
9) Confidence 0.58 Published 1998 Journal J. Med. Primatol. Section Abstract Doc Link 9606036 Disease Relevance 0.23 Pain Relevance 0.36
This study was designed to verify if the decrease in blood prolactin (PRL) induced by selective face cooling during exercise could be part of a response to specific body thermal stress.
Negative_regulation (decrease) of Positive_regulation (induced) of PRL in face associated with stress
10) Confidence 0.58 Published 1989 Journal Eur J Appl Physiol Occup Physiol Section Abstract Doc Link 2527748 Disease Relevance 0.17 Pain Relevance 0
For controls, the elevated PRL levels were reduced with bromocryptine, a dopamine receptor agonist.
Negative_regulation (reduced) of Positive_regulation (elevated) of PRL associated with dopamine receptor and agonist
11) Confidence 0.58 Published 1995 Journal Endocrinology Section Abstract Doc Link 7750466 Disease Relevance 0.07 Pain Relevance 0.49
Indomethacin blocked the chlorpormazine-induced PGF rise but not prolactin increase.
Negative_regulation (blocked) of Neg (not) Positive_regulation (increase) of prolactin
12) Confidence 0.58 Published 1975 Journal Prostaglandins Section Abstract Doc Link 1197794 Disease Relevance 0.06 Pain Relevance 0.10
In addition, the ADX-induced high basal and stressed PRL levels were restored to intact values by the low dose of DEX, and completely suppressed by the high dose of DEX.
Negative_regulation (suppressed) of Positive_regulation (induced) of PRL associated with dexamethasone
13) Confidence 0.58 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 1974081 Disease Relevance 0.15 Pain Relevance 0.50
Furthermore, the 5-hydroxytryptophan-induced increase in PRL was blocked by pretreatment with naloxone.
Negative_regulation (blocked) of Positive_regulation (increase) of PRL associated with narcan
14) Confidence 0.58 Published 1986 Journal Endocrinology Section Abstract Doc Link 3002767 Disease Relevance 0.38 Pain Relevance 0.82
Intraperitoneal administration of phencyclidine (PCP, 2.5-20 mg/kg) produced a dose-related inhibition of the increase in serum PRL concentrations produced by alpha-methylparatyrosine (AMPT) or reserpine, but not morphine.
Negative_regulation (inhibition) of Positive_regulation (increase) of PRL associated with morphine
15) Confidence 0.58 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 4007050 Disease Relevance 0 Pain Relevance 0.27
Pretreatment with naloxone prevented the increase on prolactin levels induced by DAMGO.
Negative_regulation (prevented) of Positive_regulation (increase) of prolactin associated with narcan
16) Confidence 0.58 Published 2004 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 15176435 Disease Relevance 0.09 Pain Relevance 0.67
Naloxone blocked increases in serum GH, PRL and CS and the decrease in TSH caused by METH.
Negative_regulation (blocked) of Positive_regulation (increases) of PRL associated with narcan and methadone
17) Confidence 0.57 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6653672 Disease Relevance 0 Pain Relevance 1.02
The proposed protocol successfully suppresses prolactin increase during surgery and constitutes a useful tool for investigating hyperprolactinemia and its consequences during this same time.
Negative_regulation (suppresses) of Positive_regulation (increase) of prolactin associated with galactorrhea
18) Confidence 0.57 Published 1985 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 3904312 Disease Relevance 0.17 Pain Relevance 0.15
The administration of the antianxiety drugs chlordiazepoxide (10 mg/kg i.p.) or midazolam (0.125-2 mg/kg i.p.) blocked the stress-induced increase in prolactin levels but not the stress-induced rise in plasma renin activity.
Negative_regulation (blocked) of Positive_regulation (increase) of prolactin in plasma associated with stress and versed
19) Confidence 0.56 Published 1985 Journal Brain Res. Section Abstract Doc Link 2994844 Disease Relevance 0.98 Pain Relevance 0.29
The coinfusion of either a serotonin (5-HT) or a D(1) dopamine (DA) receptor antagonist with dynorphin prevented the increase in PRL observed in birds when dynorphin was infused alone.
Negative_regulation (prevented) of Positive_regulation (increase) of PRL associated with dopamine, dynorphin, antagonist and serotonin
20) Confidence 0.54 Published 1999 Journal Neuroendocrinology Section Abstract Doc Link 10567857 Disease Relevance 0 Pain Relevance 0.98

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox