INT19771

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Context Info
Confidence 0.61
First Reported 1983
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 69
Total Number 72
Disease Relevance 75.61
Pain Relevance 76.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PAG1) plasma membrane (PAG1) intracellular (PAG1)
Anatomy Link Frequency
neurons 10
PAG 5
brain structures 2
blood 2
lateral 2
PAG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central grey 2209 100.00 Very High Very High Very High
Rostral ventromedial medulla 767 100.00 Very High Very High Very High
amygdala 742 100.00 Very High Very High Very High
midbrain 192 100.00 Very High Very High Very High
Lasting pain 142 100.00 Very High Very High Very High
Anterior cingulate cortex 118 100.00 Very High Very High Very High
Periaqueductal grey 108 100.00 Very High Very High Very High
Hippocampus 94 100.00 Very High Very High Very High
Thalamus 86 100.00 Very High Very High Very High
Somatosensory cortex 44 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2802 100.00 Very High Very High Very High
Pain 1026 100.00 Very High Very High Very High
Causalgia 6 99.96 Very High Very High Very High
Anxiety Disorder 910 99.84 Very High Very High Very High
Nociception 99 99.74 Very High Very High Very High
Stress 822 99.48 Very High Very High Very High
Inflammatory Pain 79 99.48 Very High Very High Very High
INFLAMMATION 90 99.36 Very High Very High Very High
Panic Disorder 468 99.28 Very High Very High Very High
Head & Neck Cancer 2 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we hypothesize that the activation of PAG may also be related to the itch modulation.
Positive_regulation (activation) of PAG in PAG associated with pruritus and urological neuroanatomy
1) Confidence 0.61 Published 2003 Journal Pain Section Abstract Doc Link 14499452 Disease Relevance 1.51 Pain Relevance 0.60
in the behavior of rats due to the stimulation of the dorsal PAG, Gentil
Positive_regulation (stimulation) of PAG in dorsal associated with urological neuroanatomy
2) Confidence 0.59 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2654309 Disease Relevance 1.59 Pain Relevance 0.11
Thus stimulation of the PAG may partly control pain by reducing sympathetic activity as predicted by William James over a century ago.
Positive_regulation (stimulation) of PAG in sympathetic associated with pain and urological neuroanatomy
3) Confidence 0.59 Published 2006 Journal Pain Section Abstract Doc Link 16781077 Disease Relevance 1.14 Pain Relevance 0.84
immunohistochemistry to map the activation of the PAG-RVM pathway following
Positive_regulation (activation) of PAG-RVM associated with central grey and rostral ventromedial medulla
4) Confidence 0.53 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 0.68 Pain Relevance 1.97
differences in PAG-RVM output neuron activation do not appear to contribute to
Positive_regulation (activation) of PAG-RVM in output neuron associated with central grey and rostral ventromedial medulla
5) Confidence 0.53 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.10 Pain Relevance 1.39
Activation of the PAG and its
Positive_regulation (Activation) of PAG associated with central grey
6) Confidence 0.53 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.63 Pain Relevance 1.56
twofold greater activation of PAG neurons compared to saline administration [84].
Positive_regulation (activation) of PAG in neurons associated with central grey
7) Confidence 0.53 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.33 Pain Relevance 1.83
role of PAG in fear reactions and defensive behavior to proximal threats, but data
Positive_regulation (role) of PAG in proximal associated with anxiety disorder and urological neuroanatomy
8) Confidence 0.43 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2654309 Disease Relevance 1.45 Pain Relevance 0.26
was no sex difference in the activation of the PAG following three doses or six
Positive_regulation (activation) of PAG associated with central grey
9) Confidence 0.41 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 0.55 Pain Relevance 1.86
They indicate that combined electrical stimulation of the PAG and sensory thalamus is a technically feasible and clinically satisfactory modality for the control of pain in humans, and they appear to indicate that better pain control is obtained by continuous, cycled stimulation of the PAG than by the conventional mode of stimulation.
Positive_regulation (stimulation) of PAG in PAG associated with pain, urological neuroanatomy and thalamus
10) Confidence 0.41 Published 1983 Journal Appl Neurophysiol Section Abstract Doc Link 6608316 Disease Relevance 1.00 Pain Relevance 0.77
Evoked trigeminal neuronal activity in the spinal cord was reversibly inhibited by stimulation of the PAG.
Positive_regulation (stimulation) of PAG in spinal cord associated with periaqueductal grey and spinal cord
11) Confidence 0.41 Published 2001 Journal Neuroscience Section Abstract Doc Link 11682164 Disease Relevance 1.35 Pain Relevance 1.01
We propose that the differences in NCF and right PAG activation observed may represent a greater nocifensive response and greater emotive salience of visceral over somatic pain.
Positive_regulation (activation) of PAG in visceral associated with pain, somatic pain and central grey
12) Confidence 0.41 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16093383 Disease Relevance 0.95 Pain Relevance 1.00
The present study was designed to determine whether PAG stimulation produces the release of serotonin (5-HT), norepinephrine (NE), Gly, and gamma-aminobutyric acid in the spinal cord dorsal horn and whether the release of these neurotransmitters by PAG stimulation is associated with a long-lasting inhibition of the evoked nociceptive responses of dorsal horn neurons.
Positive_regulation (stimulation) of PAG in neurons associated with nociception, neurotransmitter, dorsal horn, dorsal horn neuron, serotonin, central grey and spinal cord
13) Confidence 0.40 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215665 Disease Relevance 0.74 Pain Relevance 0.97
Acute traumatic nociceptive pain prominently activated the hypothalamus and periaqueductal gray (PAG).
Positive_regulation (activated) of PAG in hypothalamus associated with painful pain and central grey
14) Confidence 0.40 Published 1996 Journal Pain Section Abstract Doc Link 8740608 Disease Relevance 1.57 Pain Relevance 1.10
The distribution of neurons expressing the protein product (fos) of the c-fos immediate early gene were examined in the rostral medulla and caudal pons of the cat after (i) sham, (ii) stimulation of the superior sagittal sinus, (iii) stimulation of the superior sagittal sinus with PAG stimulation, or (iv) stimulation of the PAG alone.
Positive_regulation (stimulation) of PAG in superior sagittal sinus associated with medulla and central grey
15) Confidence 0.40 Published 2005 Journal Brain Res. Section Abstract Doc Link 15910757 Disease Relevance 0.94 Pain Relevance 0.96
Distraction significantly increased the activation of the cingulo-frontal cortex including the orbitofrontal and perigenual anterior cingulate cortex (ACC), as well as the periaquaeductal gray (PAG) and the posterior thalamus.
Positive_regulation (activation) of PAG in posterior associated with urological neuroanatomy, thalamus and anterior cingulate cortex
16) Confidence 0.40 Published 2004 Journal Pain Section Abstract Doc Link 15157701 Disease Relevance 1.26 Pain Relevance 1.34
FMRI data revealed brainstem activation in the PAG during the anticipation period.
Positive_regulation (activation) of PAG in brainstem associated with medulla and urological neuroanatomy
17) Confidence 0.40 Published 2007 Journal Pain Section Abstract Doc Link 17070996 Disease Relevance 0.56 Pain Relevance 0.74
patients submitted to the stimulation of the PAG report feelings of terror or
Positive_regulation (stimulation) of PAG associated with urological neuroanatomy
18) Confidence 0.40 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2654309 Disease Relevance 1.68 Pain Relevance 0.14
that electrical and chemical stimulations of the PAG cause urgent defensive
Positive_regulation (stimulations) of PAG associated with urological neuroanatomy
19) Confidence 0.40 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2654309 Disease Relevance 1.29 Pain Relevance 0.30
The electrical stimulation of the PAG in neurosurgical patients induces panic-like symptoms and the effect of drugs that are effective in the treatment of PD in the simulation of public speaking model of anxiety is in agreement with data from animal models of PD.
Positive_regulation (stimulation) of PAG in PAG associated with panic disorder, anxiety disorder and urological neuroanatomy
20) Confidence 0.40 Published 2009 Journal Neural Plasticity Section Abstract Doc Link PMC2654309 Disease Relevance 1.31 Pain Relevance 0.23

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