INT197715
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The following NRTI inhibitors of HIV-1 RT were tested in our XMRV replication assays: ZDV, 3? | |||||||||||||||
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Inhibition of RT activity (see Figure 2) was averaged over 36 experiments, each performed in duplicate, and used to calculate the median (EC50) and 90% effective concentrations (EC90) for each compound (Figure 1). | |||||||||||||||
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We chose several drugs from each major class of antiretroviral agents: nucleoside and non-nucleoside RT inhibitors (NRTIs and NNRTIs), IN inhibitors, and PR inhibitors (PI). | |||||||||||||||
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The use of RT in combination with ADT for CaP patients is clearly supported by multiple randomized trials.46,47 However, several questions remain unanswered, including the optimal sequencing and duration of androgen deprivation. | |||||||||||||||
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Conversely the in vitro inhibition of HTLV-I RT by zidovudine has been confirmed[27]. | |||||||||||||||
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The thymidine analogue, zidovudine, which inhibits HTLV-I RT in vitro[17,18] and in a rabbit infection model[19], was reported to show no clinical benefit in a study of six patients with chronic disease[20] but associated with improved mobility is some patients in a second study[21]. | |||||||||||||||
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Relative values >1 imply an increase (associated with high risk for RP according to the literature), values <1 imply a decrease of the plasma levels at the end of RT compared to the pre-RT levels (associated with low risk for RP) [15], [16], [17], [18], [22]. | |||||||||||||||
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The aggressive nature of the tumor itself may have contributed to the observed decrease in pre-RT aortic diameter, and residual tumor after gross surgical resection may have caused the subsequent decreased rate of aortic growth. | |||||||||||||||
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General Comments
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