INT197715

Context Info Confidence 0.10 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 4.35 Pain Relevance 0.18

transferase activity, transferring glycosyl groups (POMT1) endoplasmic reticulum (POMT1) extracellular matrix organization (POMT1) carbohydrate metabolic process (POMT1)

Anatomy Link Frequency plasma 1 POMT1 (Homo sapiens)

Pain Link Frequency Relevance Heat corticosteroid 7 87.12 cytokine 53 79.76 imagery 9 52.64 Spinal cord 2 47.84 ischemia 8 39.84 cryotherapy 14 5.00 Inflammation 10 5.00 Pain 8 5.00 Potency 5 5.00 Acupuncture 3 5.00

Disease Link Frequency Relevance Heat Prostate Cancer 113 100.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 96 100.00 Residual Neoplasm 1 99.12 Cancer 147 99.10 Radiation Pneumonitis 56 99.02 Infection 53 98.68 Disease 91 98.60 Chronic Disease 2 94.92 Toxicity 27 94.56 Syndrome 22 88.72

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The following NRTI inhibitors of HIV-1 RT were tested in our XMRV replication assays: ZDV, 3?

Negative_regulation (inhibitors) of RT associated with acquired immune deficiency syndrome or hiv infection

1) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2848589 Disease Relevance 0.36 Pain Relevance 0

Inhibition of RT activity (see Figure 2) was averaged over 3–6 experiments, each performed in duplicate, and used to calculate the median (EC50) and 90% effective concentrations (EC90) for each compound (Figure 1).

Negative_regulation (Inhibition) of RT

2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2848589 Disease Relevance 0.42 Pain Relevance 0

We chose several drugs from each major class of antiretroviral agents: nucleoside and non-nucleoside RT inhibitors (NRTIs and NNRTIs), IN inhibitors, and PR inhibitors (PI).

Negative_regulation (inhibitors) of RT

3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2848589 Disease Relevance 0.58 Pain Relevance 0

The use of RT in combination with ADT for CaP patients is clearly supported by multiple randomized trials.46,47 However, several questions remain unanswered, including the optimal sequencing and duration of androgen deprivation.

Negative_regulation (supported) of RT associated with prostate cancer

4) Confidence 0.07 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.78 Pain Relevance 0

Conversely the in vitro inhibition of HTLV-I RT by zidovudine has been confirmed[27].

Negative_regulation (inhibition) of RT

5) Confidence 0.05 Published 2006 Journal Retrovirology Section Body Doc Link PMC1590049 Disease Relevance 0.17 Pain Relevance 0

The thymidine analogue, zidovudine, which inhibits HTLV-I RT in vitro[17,18] and in a rabbit infection model[19], was reported to show no clinical benefit in a study of six patients with chronic disease[20] but associated with improved mobility is some patients in a second study[21].

Negative_regulation (inhibits) of RT associated with chronic disease and infection

6) Confidence 0.05 Published 2006 Journal Retrovirology Section Body Doc Link PMC1590049 Disease Relevance 0.68 Pain Relevance 0.11

Relative values >1 imply an increase (associated with high risk for RP according to the literature), values <1 imply a decrease of the plasma levels at the end of RT compared to the pre-RT levels (associated with low risk for RP) [15], [16], [17], [18], [22].

Negative_regulation (decrease) of RT in plasma associated with radiation pneumonitis

7) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483418 Disease Relevance 0.81 Pain Relevance 0.04

The aggressive nature of the tumor itself may have contributed to the observed decrease in pre-RT aortic diameter, and residual tumor after gross surgical resection may have caused the subsequent decreased rate of aortic growth.

Negative_regulation (decrease) of pre-RT associated with residual neoplasm and cancer

8) Confidence 0.01 Published 2009 Journal Pediatr Radiol Section Body Doc Link PMC2765626 Disease Relevance 0.55 Pain Relevance 0.03

General Comments

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