INT197720

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.75
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lymphocyte 3
HTLVR (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 8 93.76 High High
adenocard 5 93.24 High High
corticosteroid 21 90.32 High High
cytokine 7 67.44 Quite High
Inflammation 16 59.44 Quite High
Spinal cord 8 51.04 Quite High
Pain 21 5.00 Very Low Very Low Very Low
visual analogue scale 7 5.00 Very Low Very Low Very Low
Pain score 7 5.00 Very Low Very Low Very Low
Paresthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 77 99.32 Very High Very High Very High
Disease 67 85.96 High High
Rare Diseases 7 84.24 Quite High
Chronic Disease 7 83.12 Quite High
Necrosis 14 69.40 Quite High
Cancer 16 69.04 Quite High
INFLAMMATION 9 59.44 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 23 56.08 Quite High
Hepatitis 7 55.44 Quite High
Spinal Cord Diseases 29 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many metabolites were downregulated in the HTLV1 transformed cells, e.g., spermine, choline, phosphocholine, glycerophosphocholine, and glutathione, whereas the levels of pyrrolidine, creatine, arginine, dopamine and adenosine monophosphate were upregulated.


Negative_regulation (downregulated) of HTLV1 associated with adenocard and dopamine
1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.09
Thus, whilst a reduction in HTLV-I viral DNA during therapy with lamivudine has been documented in vivo, there are now conflicting reports of its activity against HTLV-I RT in vitro [24-26].
Negative_regulation (reduction) of HTLV-I
2) Confidence 0.03 Published 2006 Journal Retrovirology Section Body Doc Link PMC1590049 Disease Relevance 0.19 Pain Relevance 0
Some nucleoside analogues have been shown to inhibit HTLV-I reverse transcriptase.
Negative_regulation (inhibit) of HTLV-I
3) Confidence 0.03 Published 2006 Journal Retrovirology Section Body Doc Link PMC1590049 Disease Relevance 0.60 Pain Relevance 0.15
A decrease in HTLV-I viral DNA and thus a presumed decrease in viral antigen burden has been associated with a reduction in HTLV-I specific CTL lymphocyte activity[22].
Negative_regulation (decrease) of HTLV-I in lymphocyte
4) Confidence 0.03 Published 2006 Journal Retrovirology Section Body Doc Link PMC1590049 Disease Relevance 0.14 Pain Relevance 0
A decrease in HTLV-I viral DNA and thus a presumed decrease in viral antigen burden has been associated with a reduction in HTLV-I specific CTL lymphocyte activity[22].
Negative_regulation (reduction) of HTLV-I in lymphocyte
5) Confidence 0.03 Published 2006 Journal Retrovirology Section Body Doc Link PMC1590049 Disease Relevance 0.16 Pain Relevance 0
Conversely the in vitro inhibition of HTLV-I RT by zidovudine has been confirmed[27].
Negative_regulation (inhibition) of HTLV-I
6) Confidence 0.03 Published 2006 Journal Retrovirology Section Body Doc Link PMC1590049 Disease Relevance 0.17 Pain Relevance 0
Changes in the lymphocyte markers of activation and proliferation might have been expected with a reduction in HTLV-I proviral load.
Negative_regulation (reduction) of HTLV-I in lymphocyte
7) Confidence 0.03 Published 2006 Journal Retrovirology Section Body Doc Link PMC1590049 Disease Relevance 0.37 Pain Relevance 0.03
Since monotherapy with nucleoside analogues had been reported to reduce HTLV-I viral load, the inhibition of HTLV-I reverse transcriptase by two nucleoside analogues, zidovudine and lamivudine was thought to be more likely to cause a sustained decrease in HTLV-I viral burden than either drug alone.
Negative_regulation (decrease) of HTLV-I
8) Confidence 0.03 Published 2006 Journal Retrovirology Section Body Doc Link PMC1590049 Disease Relevance 0.13 Pain Relevance 0

General Comments

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