INT197721

Context Info Confidence 0.35 First Reported 2006 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 36 Total Number 36 Disease Relevance 20.08 Pain Relevance 1.03

Anatomy Link Frequency arm 34 foot 1 head 1 ARMC9 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain score 3 98.92 rheumatoid arthritis 51 98.36 imagery 73 96.64 cva 45 86.08 Paresthesia 3 85.00 Arthritis 98 82.52 Pain 58 78.92 Spinal cord 8 57.80 nerve block 1 54.24 Angina 8 49.36

Disease Link Frequency Relevance Heat Infection 140 100.00 Arthralgia 40 100.00 Disorders Of Creatine Metabolism 12 99.98 Diarrhoea 66 99.90 Lymphedema 49 99.78 Exanthema 44 99.64 Overactive Bladder 12 99.54 Breast Cancer 279 99.40 Toxicity 142 99.34 Incontinence 7 99.30

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CPK elevation was more common in Arm B (45.0% of patients and 12.2% of cycles) than in Arm A (31.6% of patients, 8.4% of cycles).

Positive_regulation (elevation) of Arm B in Arm associated with disorders of creatine metabolism

1) Confidence 0.35 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2666889 Disease Relevance 2.07 Pain Relevance 0

The second trial is a comparison of prednisolone versus megestrol acetate; those in the megestrol acetate arm did significantly worse [10].

Positive_regulation (acetate) of arm in arm

2) Confidence 0.34 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2330150 Disease Relevance 0.66 Pain Relevance 0.04

As a result of this study arm, the speed that the lithium dose may be increased (weekly vs. twice weekly) in children and adolescents will be determined.

Positive_regulation (result) of arm in arm

3) Confidence 0.32 Published 2008 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC2531078 Disease Relevance 0.06 Pain Relevance 0

Toxicity from skin rash and diarrhea was increased in the erlotinib arm although there were no significant differences for global quality-of-life scores (Moore et al. 2005).

Positive_regulation (increased) of arm in arm associated with exanthema, toxicity and diarrhoea

4) Confidence 0.23 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012429 Disease Relevance 0.55 Pain Relevance 0

Limitations, including the previously described detection bias for MI [55] and unbalancing of adjunctive therapies following randomization (less platelet IIb/IIIa blockade during cross-over PCI in the conservative arm than in the invasive arm and more oral antiplatelet therapy in the invasive arm) cloud any interpretation of superiority.

Positive_regulation (conservative) of arm in arm associated with myocardial infarction

5) Confidence 0.21 Published 2006 Journal BMC Med Section Body Doc Link PMC1617111 Disease Relevance 0.71 Pain Relevance 0.06

Limitations, including the previously described detection bias for MI [55] and unbalancing of adjunctive therapies following randomization (less platelet IIb/IIIa blockade during cross-over PCI in the conservative arm than in the invasive arm and more oral antiplatelet therapy in the invasive arm) cloud any interpretation of superiority.

Positive_regulation (conservative) of arm in arm associated with myocardial infarction

6) Confidence 0.21 Published 2006 Journal BMC Med Section Body Doc Link PMC1617111 Disease Relevance 0.63 Pain Relevance 0.03

A superficial vein of the ipsilateral arm was also cannulated for infusion of insulin and glucose (see below).

Positive_regulation (cannulated) of arm in arm

7) Confidence 0.14 Published 2008 Journal Diabetes Section Body Doc Link PMC2453632 Disease Relevance 0.31 Pain Relevance 0

A priori there is no reason why participants who felt the illusion of ownership to some extent might not also give relatively high scores to these questions: a confusion about the location of the felt touch (Q5), that their arm was virtual (indeed it would be so!)

Positive_regulation (indeed) of arm in arm associated with confusion

8) Confidence 0.14 Published 2008 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2572198 Disease Relevance 0.10 Pain Relevance 0

Of the children classified with nonsevere pneumonia, 13.3% of those in the control arm received early and appropriate treatment with amoxicillin compared to 68.2% of those in the intervention arm, a 5-fold increase in the timely treatment for pneumonia.

Positive_regulation (increase) of arm in arm associated with pneumonia

9) Confidence 0.14 Published 2010 Journal PLoS Medicine Section Abstract Doc Link PMC2943441 Disease Relevance 1.35 Pain Relevance 0

In every BCRL untreated arm, the rates of lymphatic propulsion increased post-treatment as compared to pre-treatment and in 4 of 6 arms, the rates increased during treatment as compared to pre-treatment (Fig. 7A).

Positive_regulation (increased) of arm in arms associated with lymphedema

10) Confidence 0.14 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3005162 Disease Relevance 0.56 Pain Relevance 0

70 years) patients.45 However, a recently published phase III trial of GD vs docetaxel alone in elderly patients and subjects with poor performance status showed no survival improvement for the combination arm, suggesting that single agent chemotherapy should remain the standard of care for these groups of patients.46

Neg (no) Positive_regulation (improvement) of arm in arm

11) Confidence 0.13 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886326 Disease Relevance 0.42 Pain Relevance 0

In the Spanish study, 135 patients with advanced disease were randomly assigned to cisplatin with etoposide or gemcitabine.14 Despite the lack of a survival benefit, patients treated in the experimental arm reported a significantly higher response rate (40.6% vs 21.9%, P = 0.02) and time to progression (6.9 vs 4.3 months, P = 0.01), with an overall similar toxicity profile.

Positive_regulation (experimental) of arm in arm associated with toxicity and disease

12) Confidence 0.13 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886326 Disease Relevance 0.70 Pain Relevance 0

Lymphocyte subset analysis of the first, randomised therapy phase of the study, showed an increase in CD4 in both arms and an increase in CD8 cells in the placebo arm but a decrease in the active arm (Table 3).

Positive_regulation (increase) of arm in arms

13) Confidence 0.10 Published 2006 Journal Retrovirology Section Body Doc Link PMC1590049 Disease Relevance 0 Pain Relevance 0

During the first 24 weeks the mean total lymphocyte counts (AUCMB) increased by 148 × 106/L in the placebo arm but decreased by 159 × 106/L in the active arm, a mean difference of 307 × 106/L (SE = 158, p = 0.07) (Table 3).

Positive_regulation (increased) of arm in arm

14) Confidence 0.10 Published 2006 Journal Retrovirology Section Body Doc Link PMC1590049 Disease Relevance 0.21 Pain Relevance 0.05

The first arm included HER2 positive breast cancer patients who were previously treated with trastuzumab and the second arm included advanced HER2 positive breast cancer patients with no prior trastuzumab treatment.

Positive_regulation (advanced) of arm in arm associated with breast cancer

15) Confidence 0.10 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2579406 Disease Relevance 1.23 Pain Relevance 0.05

Importantly, patients in the supportive care arm were allowed to cross over to the azacitidine arm after at least 4 months of supportive care or if they met other criteria for worsening disease status prior to that time.9

Positive_regulation (supportive) of arm in arm associated with disease

16) Confidence 0.10 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2939768 Disease Relevance 0.45 Pain Relevance 0

Moreover, the results of the BIG 1–98 study indicate a statistically significant increase in fracture number in the letrozole arm with respect to the tamoxifen arm (9% vs 6%) (Viale et al 2007).

Positive_regulation (increase) of arm in arm

17) Confidence 0.10 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 0.36 Pain Relevance 0

Moreover, the results of the BIG 1–98 study indicate a statistically significant increase in fracture number in the letrozole arm with respect to the tamoxifen arm (9% vs 6%) (Viale et al 2007).

Positive_regulation (increase) of arm in arm

18) Confidence 0.10 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 0.36 Pain Relevance 0

In a phase III randomized clinical trial of chemo-naive MBC patients coordinated by the Eastern Cooperative Oncology Group (ECOG) E2100, paclitaxel 90 mg/m2 in combination with bevacizumab 10 mg/kg was compared to paclitaxel alone.[23] The patients in the combination arm achieved a significantly longer PFS compared to the paclitaxel monotherapy arm (11.4 months vs 6.11 months) and a significantly increased ORR (30% vs 14%).

Positive_regulation (increased) of arm in arm associated with advanced or metastatic breast cancer

19) Confidence 0.09 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2579406 Disease Relevance 0.54 Pain Relevance 0

In fact in the ATAC trial there was a significant increase in arthralgias in the anastrozole arm when compared to the tamoxifen arm (35.6% vs 29.4%; p < 0.001) (ATAC Trialists’ Group 2005).

Positive_regulation (increase) of arm in arm associated with arthralgia

20) Confidence 0.09 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 1.25 Pain Relevance 0.12

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