INT19775

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2011
Negated 6
Speculated 0
Reported most in Body
Documents 183
Total Number 184
Disease Relevance 145.50
Pain Relevance 50.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 25
monocytes 13
neutrophils 5
mononuclear cells 5
immune cells 3
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 5600 100.00 Very High Very High Very High
cytokine 3670 100.00 Very High Very High Very High
chemokine 414 100.00 Very High Very High Very High
Inflammatory mediators 355 100.00 Very High Very High Very High
Potency 131 100.00 Very High Very High Very High
noradrenaline 14 99.98 Very High Very High Very High
Spinal cord 141 99.92 Very High Very High Very High
Morphine 40 99.70 Very High Very High Very High
antagonist 646 99.60 Very High Very High Very High
Glutamate 39 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 6581 100.00 Very High Very High Very High
Cancer 956 100.00 Very High Very High Very High
Necrosis 275 100.00 Very High Very High Very High
Adhesions 275 100.00 Very High Very High Very High
Hypoxia 275 100.00 Very High Very High Very High
Osteoporosis 66 100.00 Very High Very High Very High
Disease 2098 99.98 Very High Very High Very High
Fever 308 99.80 Very High Very High Very High
Arthritis 937 99.76 Very High Very High Very High
Syndrome 264 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These genes are regulated separately, and coordinated induction in the same cell is required for secretion of the biologically active IL-12p70 heterodimer [236].
Localization (secretion) of IL-1
1) Confidence 0.78 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.14 Pain Relevance 0.06
These agents appear to function by blocking the release of TNF alpha and IL-1 from macrophages as well as competition with their respective high affinity receptors on target tissue, eg. fibroblasts, and macrophages.
Localization (release) of IL-1 in macrophages
2) Confidence 0.76 Published 1996 Journal Biomed. Pharmacother. Section Abstract Doc Link 8952870 Disease Relevance 0.36 Pain Relevance 0.25
This behavioral response to IL-1 administration is consistent with the behavioral effects of IL-1 reported previously, and strengthens the hypothesis that IL-1 secretion may be responsible for behavioral changes associated with immune activation.
Localization (secretion) of IL-1
3) Confidence 0.74 Published 1990 Journal Brain Behav. Immun. Section Abstract Doc Link 2092866 Disease Relevance 0 Pain Relevance 0.24
, were established by incubating HUVEC in the presence of IL-1?
Localization (presence) of IL-1
4) Confidence 0.73 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.70 Pain Relevance 0
In fact, many shared genes are readily identified as being immune related, such as immunity related GTPase, very large Ifn inducible GTPase, IL1?
Localization (related) of IL1
5) Confidence 0.73 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2939656 Disease Relevance 0.42 Pain Relevance 0.18
Furthermore, LPS-induced IL-1 production by macrophages (in the absence of added beta-endorphin) was also partially inhibited following treatment with naloxone, suggesting that opioids derived from activated macrophages may also modulate IL-1 generation and secretion.
Localization (secretion) of IL-1 in macrophages associated with narcan and opioid
6) Confidence 0.71 Published 1989 Journal Int. Immunol. Section Abstract Doc Link 2535139 Disease Relevance 0 Pain Relevance 0.32
Implantation of slow release IL-1?
Localization (release) of IL-1
7) Confidence 0.69 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.53 Pain Relevance 0.03
In part, the ability of these agents to suppress the inflammatory process is due to their blockage of cytokine release, e.g.TNF alpha and IL-1, as well as their inhibition of high affinity binding to receptors on target cells of inflammation.
Localization (release) of IL-1 associated with inflammation and cytokine
8) Confidence 0.66 Published 1996 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 8687282 Disease Relevance 0.55 Pain Relevance 0.36
In part they appear to mediate their effects due to their ability to suppress the release of cytokines such as TNF alpha and IL-1 from macrophages, as well as the binding of these cytokines to high-affinity receptors on target cells involved in the inflammation process.
Localization (release) of IL-1 in macrophages associated with inflammation and cytokine
9) Confidence 0.66 Published 1996 Journal Int J Tissue React Section Abstract Doc Link 9063766 Disease Relevance 0.45 Pain Relevance 0.33
Postoperative incisional pain is characterized by persistent acute pain in the area of the cut, and is associated with release of proinflammatory cytokines, including interleukin-1 (IL-1), which play important hyperalgesic and allodynic roles in various inflammatory conditions.
Localization (release) of IL-1 associated with pain, hyperalgesia, inflammation, acute pain and cytokine
10) Confidence 0.65 Published 2008 Journal Brain Behav. Immun. Section Abstract Doc Link 18442892 Disease Relevance 0.77 Pain Relevance 0.49
Further support for IL-1?
Localization (support) of IL-1
11) Confidence 0.64 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.45 Pain Relevance 0
In Down's syndrome, where patients are predisposed to AD neuropathological changes, IL-1 elevation and neuroinflammation precede by years the formation of plaques [119].
Localization (elevation) of IL-1 in plaques associated with syndrome and alzheimer's dementia
12) Confidence 0.64 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.46 Pain Relevance 0.07
Implantation of slow release IL-1?
Localization (release) of IL-1
13) Confidence 0.64 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.53 Pain Relevance 0.03
Apart from the inflammasome, IL-1 secretion by macrophages in contact with MSU can also be induced through a TLR-dependent mechanism [5].
Localization (secretion) of IL-1 in macrophages associated with crystal associated disease
14) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.69 Pain Relevance 0.20
The recent finding that MSU crystals induce IL-1 release by activation of the NALP3 inflammasome led us to investigate whether IL-1 blockade could inhibit inflammation provoked by MSU.
Localization (release) of IL-1 associated with inflammation and crystal associated disease
15) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 1.05 Pain Relevance 0.40
A pilot study of IL-1 inhibition by anakinra in acute gout

Monosodium urate crystals stimulate monocytes and macrophages to release IL-1?

Localization (release) of IL-1 in monocytes associated with anakinra and crystal associated disease
16) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC1906806 Disease Relevance 0.92 Pain Relevance 0.24
MSU and calcium pyrophosphate dihydrate crystals directly activate the inflammasome via NALP3 in monocytes or macrophages to release active IL-1?
Localization (release) of IL-1 in macrophages associated with crystal associated disease
17) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.77 Pain Relevance 0.18
to release the mature p17 form of IL-1?.
Localization (release) of IL-1
18) Confidence 0.52 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.81 Pain Relevance 0.26
Especially, the mechanisms of degeneration of the joint cartilage seem to be induced by IL1 secretion in the synovium.
Localization (secretion) of IL1 in synovium
19) Confidence 0.49 Published 1988 Journal Rev Rhum Mal Osteoartic Section Abstract Doc Link 3134688 Disease Relevance 0.45 Pain Relevance 0.32
Among the many cytokines implicated [2,3], IL-1 may have a special role in the inflammatory network, as MSU crystals stimulate IL-1 release by monocytes and synovial mononuclear cells [4].
Localization (release) of IL-1 in mononuclear cells associated with inflammation, crystal associated disease and cytokine
20) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.96 Pain Relevance 0.39

General Comments

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