INT197765

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 26
Total Number 29
Disease Relevance 12.11
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (Sln)
Anatomy Link Frequency
lymph node 2
Node 2
skin 2
esophagus 1
body 1
Sln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 49 87.88 High High
Bioavailability 61 82.16 Quite High
transdermal 90 75.00 Quite High
anesthesia 20 71.20 Quite High
imagery 32 65.92 Quite High
Thoracotomy 5 63.92 Quite High
Neuritis 1 18.88 Low Low
Pain 12 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
carrageenan induced 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 570 100.00 Very High Very High Very High
Melanoma 45 99.20 Very High Very High Very High
Stomach Cancer 17 98.92 Very High Very High Very High
Metastasis 254 98.84 Very High Very High Very High
Esophageal Cancer 130 98.64 Very High Very High Very High
Carcinoma 33 98.28 Very High Very High Very High
Skin Cancer 49 97.84 Very High Very High Very High
Noninfiltrating Intraductal Carcinoma 69 97.32 Very High Very High Very High
Diabetes Mellitus 42 96.12 Very High Very High Very High
Disease 122 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A different release kinetic was observed for the SLN dispersions and SLN gel formulations.
Gene_expression (dispersions) of SLN
1) Confidence 0.58 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2651881 Disease Relevance 0 Pain Relevance 0
Preparation of aqueous SLN and NLC dispersions of Flurbiprofen
Gene_expression (Preparation) of SLN
2) Confidence 0.58 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2651881 Disease Relevance 0 Pain Relevance 0
The rheological investigations provide information about application of semisolid formulations and their performance on skin; these studies were conducted both on SLN and NLC enriched hydrogels.
Gene_expression (conducted) of SLN in skin
3) Confidence 0.58 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2651881 Disease Relevance 0.05 Pain Relevance 0.09
Both the SLN and NLC dispersions and gels enriched with SLN and NLC possessed a sustained drug release over period of 24 h but the sustained effect was more pronounced with the SLN and NLC gel


Background

Gene_expression (pronounced) of SLN
4) Confidence 0.58 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2651881 Disease Relevance 0.18 Pain Relevance 0.12
TEM analysis suggested that immediately after production SLN and NLC formulations contained no particles higher than 1 ?
Gene_expression (production) of SLN
5) Confidence 0.52 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2651881 Disease Relevance 0 Pain Relevance 0
The mean diameters confirmed that the SLN produced are submicron colloidal carriers, suitable for enabling gastrointestinal absorption by M-cells on Peyer’s patches.
Gene_expression (produced) of SLN
6) Confidence 0.51 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676823 Disease Relevance 0 Pain Relevance 0
SLN were successfully produced by a modified solvent emulsification-evaporation method based on a w/o/w double emulsion.
Gene_expression (produced) of SLN
7) Confidence 0.51 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676823 Disease Relevance 0.06 Pain Relevance 0
Among the five patients in whom SLN could not be detected (SLN negative), only one patient was proven to have metastasis on histology.
Neg (not) Gene_expression (detected) of SLN associated with metastasis
8) Confidence 0.48 Published 2010 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC3003219 Disease Relevance 1.48 Pain Relevance 0
Among the five patients in whom SLN could not be detected (SLN negative), only one patient was proven to have metastasis on histology.
Neg (not) Gene_expression (detected) of SLN associated with metastasis
9) Confidence 0.48 Published 2010 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC3003219 Disease Relevance 1.49 Pain Relevance 0
If no lymph node stained within a period of 5 min, the patient was declared as SLN negative.
Neg (negative) Gene_expression (negative) of SLN in lymph node
10) Confidence 0.48 Published 2010 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC3003219 Disease Relevance 0.52 Pain Relevance 0.09
The SLN dispersion was further stirred for 3 h after the complete addition of microemulsion.
Gene_expression (dispersion) of SLN
11) Confidence 0.45 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792476 Disease Relevance 0 Pain Relevance 0
The amount of insulin entrapped into SLN was calculated by the difference between the total amount used to prepare the systems and the amount of insulin that remained in the aqueous phase after SLN isolation.
Gene_expression (entrapped) of SLN
12) Confidence 0.44 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676823 Disease Relevance 0.05 Pain Relevance 0
In fact, immediately after production, the pH of insulin-colloidal SLN dispersion was found to be 3.1, lower than the isoelectric point of insulin which is 5.3 (Brange 1987), responsible for the insulin positive charge.
Gene_expression (dispersion) of SLN
13) Confidence 0.44 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676823 Disease Relevance 0 Pain Relevance 0.03
The reduction of the initial glucose levels versus time after intragastric insulin-loaded SLN, insulin solution and subcutaneous administration of insulin is depicted in Figure 2.
Gene_expression (solution) of SLN
14) Confidence 0.44 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676823 Disease Relevance 0.10 Pain Relevance 0.03
In the advanced tumor stage, the lymphatics get blocked by the cancer cell permeation and emboli; the dye does not reach the SLN at all, leading to non-detection of SLNs.[1617] The detection of SLN in our study was higher in lower esophageal tumors (85%) than in mid-esophageal tumors (75%), but it was not statistically significant (P value >0.05).
Gene_expression (detection) of SLN associated with cancer and esophageal cancer
15) Confidence 0.42 Published 2010 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC3003219 Disease Relevance 0.90 Pain Relevance 0
This study aims to investigate the feasibility and accuracy of detection of SLN using methylene blue dye in patients with carcinoma of the esophagus and assess its potential role in determining the rational extent of lymphadenectomy in esophageal cancer surgery.


Gene_expression (detection) of SLN in esophagus associated with carcinoma and esophageal cancer
16) Confidence 0.42 Published 2010 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Abstract Doc Link PMC3003219 Disease Relevance 0.61 Pain Relevance 0
In many centers SLN detection has become standard clinical practice.
Gene_expression (detection) of SLN in SLN
17) Confidence 0.40 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2984381 Disease Relevance 0.77 Pain Relevance 0
SLN detection was first used in other anatomical areas like the breast and soon skin cancer as well as gastric cancers followed.
Gene_expression (detection) of SLN in skin associated with skin cancer and stomach cancer
18) Confidence 0.40 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2984381 Disease Relevance 0.78 Pain Relevance 0
Oral insulin delivery by means of solid lipid nanoparticles

The aim of this work was to produce and characterize cetyl palmitate-based solid lipid nanoparticles (SLN) containing insulin, and to evaluate the potential of these colloidal carriers for oral administration.

Gene_expression (produce) of SLN
19) Confidence 0.40 Published 2007 Journal International Journal of Nanomedicine Section Title Doc Link PMC2676823 Disease Relevance 0.08 Pain Relevance 0
SLN made of solid lipids (lipids being solid at room and body temperatures) are submicron colloidal carriers (50–1000 nm) dispersed either in water or in an aqueous surfactant solution (Rawat et al 2006).
Gene_expression (made) of SLN in body
20) Confidence 0.40 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676823 Disease Relevance 0 Pain Relevance 0

General Comments

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