INT19777

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Context Info
Confidence 0.40
First Reported 1988
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 6.65
Pain Relevance 4.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
pituitary 1
PVN 1
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 5 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
Neuropeptide 70 99.98 Very High Very High Very High
alcohol 23 99.84 Very High Very High Very High
addiction 16 99.52 Very High Very High Very High
Inflammation 21 98.04 Very High Very High Very High
cytokine 91 97.52 Very High Very High Very High
Spinal cord 14 96.44 Very High Very High Very High
amygdala 205 95.28 Very High Very High Very High
antagonist 36 94.60 High High
Disease Link Frequency Relevance Heat
Alcohol Addiction 16 99.84 Very High Very High Very High
Cancer 23 99.32 Very High Very High Very High
Anxiety Disorder 92 98.92 Very High Very High Very High
Stress 350 98.60 Very High Very High Very High
Targeted Disruption 144 98.48 Very High Very High Very High
INFLAMMATION 28 98.04 Very High Very High Very High
Metastasis 1 97.32 Very High Very High Very High
Brain Tumor 1 96.60 Very High Very High Very High
Glioblastoma 1 95.56 Very High Very High Very High
Subependymal Glioma 1 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ether-laparotomy stress resulted in a dramatic decrease in specific iodine-125-labeled ovine CRF binding ([125I]oCRF) in the pituitary at 6 h after the onset of the stress although it did not affect [125I]oCRF binding in the pituitary at 2 h after the stress. [125I]oCRF binding was unchanged in the frontal cortex after the stress.
CRF Binding (binding) of in pituitary associated with stress and urological neuroanatomy
1) Confidence 0.40 Published 1994 Journal Brain Res. Section Abstract Doc Link 7827996 Disease Relevance 0.80 Pain Relevance 0.03
These data demonstrate complex interactions between CRF and IL-1 receptors on HPA axis during stress.
CRF Binding (interactions) of associated with stress
2) Confidence 0.35 Published 1994 Journal Brain Res. Section Abstract Doc Link 7827996 Disease Relevance 0.91 Pain Relevance 0.05
This behavioral change resembled that induced following restraint or ICV injection of corticotropin-releasing factor (CRF).
CRF Binding (injection) of
3) Confidence 0.32 Published 1990 Journal Brain Behav. Immun. Section Abstract Doc Link 2092866 Disease Relevance 0 Pain Relevance 0.22
This behavioral change resembled that induced following restraint or ICV injection of corticotropin-releasing factor (CRF).
corticotropin-releasing factor Binding (injection) of
4) Confidence 0.32 Published 1990 Journal Brain Behav. Immun. Section Abstract Doc Link 2092866 Disease Relevance 0 Pain Relevance 0.22
In the systemic circulation, CRH and Ucn1 are known to bind CRH-binding protein (CRH-BP), resulting in the inactivation of CRH and Ucn1 (Potter et al. 1991).
CRH Binding (bind) of
5) Confidence 0.31 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.05 Pain Relevance 0.27
In the systemic circulation, CRH and Ucn1 are known to bind CRH-binding protein (CRH-BP), resulting in the inactivation of CRH and Ucn1 (Potter et al. 1991).
CRH-binding protein Binding (bind) of
6) Confidence 0.31 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.05 Pain Relevance 0.26
In the systemic circulation, CRH and Ucn1 are known to bind CRH-binding protein (CRH-BP), resulting in the inactivation of CRH and Ucn1 (Potter et al. 1991).
CRH Binding (bind) of
7) Confidence 0.31 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.05 Pain Relevance 0.26
This result suggests that the presence of CRH is required for the formation of the diurnal regulation of the HPA axis, but the circadian variation of CRH is not indispensable, at least in rodents.
CRH Binding (variation) of
8) Confidence 0.31 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.28 Pain Relevance 0
Vasopressin and CRH are closely linked to immune response; they also interact with pro-inflammatory cytokines.
CRH Binding (linked) of associated with inflammation and cytokine
9) Confidence 0.31 Published 2008 Journal Gene Regulation and Systems Biology Section Abstract Doc Link PMC2733102 Disease Relevance 0.28 Pain Relevance 0.14
The free acid analog of CRH, which does not interact with its receptors (CRHR), had no biological activity.
CRH Neg (not) Binding (interact) of
10) Confidence 0.30 Published 1998 Journal Endocrinology Section Abstract Doc Link 9421440 Disease Relevance 0.36 Pain Relevance 0.31
The CRF system is comprised of the neuropeptides CRF and urocortin I that bind to and activate both CRF1-receptors (CRF1-R) and CRF2-receptors; whereas the peptides urocortin II and urocortin III are more selective CRF2-receptor agonists [15], [16].
CRF Binding (bind) of associated with agonist and neuropeptide
11) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.79 Pain Relevance 0.33
In the hypothalamus, CRH-positive neurons are mainly recognized in the parvocellular subdivision of PVN, some of which are co-localized with vasopressin.
CRH Binding (recognized) of in PVN
12) Confidence 0.30 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.33
Further, corticotropin releasing factor (CRF) and its receptors (CRF1 and CRF2) are also linked to alcohol dependence and anxiety-like behaviors in rodents (Heilig and Koob, 2007; Lowery and Thiele, 2010; Roberto et al., 2010).
corticotropin releasing factor Binding (linked) of associated with addiction, anxiety disorder and alcohol
13) Confidence 0.28 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.37 Pain Relevance 0.58
Further, corticotropin releasing factor (CRF) and its receptors (CRF1 and CRF2) are also linked to alcohol dependence and anxiety-like behaviors in rodents (Heilig and Koob, 2007; Lowery and Thiele, 2010; Roberto et al., 2010).
CRF Binding (linked) of associated with addiction, anxiety disorder and alcohol
14) Confidence 0.28 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.37 Pain Relevance 0.58
CRH mainly binds CRHR1, but not CRHR2.
CRH Binding (binds) of
15) Confidence 0.26 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.06 Pain Relevance 0.20
As far as HPA axis function is concerned, clearly Crh (or Oxt) does not compensate for the loss of the Avpr1b in Avpr1b KO mice.
Crh Neg (not) Binding (compensate) of associated with targeted disruption
16) Confidence 0.15 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.44 Pain Relevance 0.04
In all 25 intracranial tumours studied, no immunoreactivity was found for vasoactive intestinal polypeptide, substance P, methionine-enkephalin, leucine-enkephalin, synenkephalin, neurophysin I-II, and corticotropin releasing factor.
corticotropin releasing factor Binding (found) of associated with cancer, enkephalin and substance p
17) Confidence 0.02 Published 1988 Journal Acta Neuropathol. Section Abstract Doc Link 2903606 Disease Relevance 0.83 Pain Relevance 0.53

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