INT197772

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 5.94
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pla2g10)
Anatomy Link Frequency
urine 2
nervous system 1
Pla2g10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 60 98.76 Very High Very High Very High
Multiple sclerosis 126 98.60 Very High Very High Very High
Spinal cord 54 87.56 High High
cINOD 6 70.96 Quite High
Inflammatory mediators 12 37.52 Quite Low
Inflammatory stimuli 6 25.84 Quite Low
Inflammatory response 18 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 336 99.66 Very High Very High Very High
Immunization 108 99.56 Very High Very High Very High
INFLAMMATION 102 98.76 Very High Very High Very High
Disease 72 98.20 Very High Very High Very High
Proteinuria 6 93.04 High High
Weight Gain 6 90.40 High High
Body Weight 18 82.76 Quite High
Infection 24 68.40 Quite High
Recurrence 12 64.40 Quite High
Paresis 12 59.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mean urinary sPLA2 activity increased steadily for the first 8 days following immunization in both treatment groups (Fig. 1, Top).
Positive_regulation (increased) of sPLA2 associated with immunization
1) Confidence 0.38 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1592473 Disease Relevance 1.24 Pain Relevance 0.11
Multiple Sclerosis patients also showed elevations in sPLA2 enzyme activity.
Positive_regulation (elevations) of sPLA2 associated with multiple sclerosis
2) Confidence 0.29 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1592473 Disease Relevance 1.05 Pain Relevance 0.04
The mean level of active sPLA2 enzymes was significantly elevated in the urine of patients with both active and stable MS (Fig. 4).
Positive_regulation (elevated) of sPLA2 in urine associated with multiple sclerosis
3) Confidence 0.29 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1592473 Disease Relevance 0.45 Pain Relevance 0.22
The present results suggest that increased levels of sPLA2 enzymes, long associated with inflammation outside the nervous system[24], also characterize Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.
Positive_regulation (increased) of sPLA2 in nervous system associated with multiple sclerosis and inflammation
4) Confidence 0.29 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1592473 Disease Relevance 0.82 Pain Relevance 0.17
Mean levels of sPLA2 were increased 6-fold in the urine of patients with active disease and 4-fold for patients in remission, regardless of immunomodulating therapy.


Positive_regulation (increased) of sPLA2 in urine associated with disease
5) Confidence 0.29 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1592473 Disease Relevance 1.04 Pain Relevance 0.04
Using a simple urinary assay for active enzyme concentration, we found that rats immunized to produce EAE had evidence of increased systemic sPLA2 following immunization.
Positive_regulation (increased) of sPLA2 associated with multiple sclerosis and immunization
6) Confidence 0.26 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1592473 Disease Relevance 1.34 Pain Relevance 0.29

General Comments

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