INT197791

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.31
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pth1r) plasma membrane (Pth1r) nucleus (Pth1r)
intracellular (Pth1r) cytoplasm (Pth1r) signal transducer activity (Pth1r)
Anatomy Link Frequency
neurons 3
stomach 1
Parathyroid 1
Pth1r (Mus musculus)
Pain Link Frequency Relevance Heat
vagus nerve 552 99.28 Very High Very High Very High
primary afferent fibers 12 80.72 Quite High
depression 76 79.16 Quite High
addiction 36 5.00 Very Low Very Low Very Low
Action potential 32 5.00 Very Low Very Low Very Low
medulla 24 5.00 Very Low Very Low Very Low
isoflurane 16 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
adenocard 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chondroma 41 91.64 High High
Cleidocranial Dysplasia 2 90.16 High High
Enchondromatosis 56 86.80 High High
Depression 76 79.16 Quite High
Congenital Anomalies 6 64.28 Quite High
Cancer 10 62.96 Quite High
Disseminated Intravascular Coagulation 20 38.28 Quite Low
Chondrosarcoma 12 37.52 Quite Low
Targeted Disruption 2 30.40 Quite Low
Malignant Neoplastic Disease 14 29.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Parathyroid hormone-related protein (PTHrP) and Indian Hedgehog (IHH) acting on their respective receptors PTHR1 and PTCH1 exert a tightly coupled signaling relay, which is critical for the regulation of endochondral ossification (Figure 2).
Regulation (acting) of PTHR1 in Parathyroid
1) Confidence 0.27 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1592482 Disease Relevance 0.98 Pain Relevance 0
To examine the hypothesis that a specific type of DMX neuron predominantly receives afferent fibers with a similar class of short-term plasticity (i.e., the type of postsynaptic neuron determines the type of afferents that converge), we analyzed the effect of changing the stimulation intensity from sub-threshold to supra-maximal levels on EPSC amplitude and PPR (Figure 2C) because this maneuver should gradually expand the population of activated afferents.
Spec (analyzed) Regulation (changing) of PPR in neuron associated with vagus nerve
2) Confidence 0.05 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2978217 Disease Relevance 0 Pain Relevance 0.27
However, the DiI(+) cells exhibited a distribution of PPR values that differed significantly from that of the entire DMX neuron population (p = 0.035, Kolmogorov-Smirnov test); i.e., those projecting to stomach (n = 21) more frequently showed larger values of PPR and those with small PPRs (e.g., <0.5) were very rare compared to the PPR distribution based on whole DMX neurons recorded (n = 120; Figure 6D; c.f., Figure 1C).
Regulation (values) of PPR in stomach associated with vagus nerve
3) Confidence 0.05 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2978217 Disease Relevance 0 Pain Relevance 0.45
The mean PPR values of type I and type II DMX neurons were 0.92 ± 0.02 (n = 63) and 0.46 ± 0.10 (n = 57), respectively.
Regulation (values) of PPR in neurons associated with vagus nerve
4) Confidence 0.05 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2978217 Disease Relevance 0.12 Pain Relevance 0.62
We classified DMX neurons in two groups because: i) these two Gaussian distributions showed the smallest overlap at a PPR value around 0.6; ii) there was a trough at around 0.6 for the distribution of PPR among DMX neurons; iii) the PPR of dm-cNTS neurons never exceeded 0.6.
Regulation (value) of PPR in neurons associated with vagus nerve
5) Confidence 0.05 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2978217 Disease Relevance 0.22 Pain Relevance 0.65

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