INT197792

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Context Info
Confidence 0.24
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.47
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pthlh) Golgi apparatus (Pthlh) nucleus (Pthlh)
intracellular (Pthlh) cytoplasm (Pthlh)
Anatomy Link Frequency
parathyroid 4
Pthlh (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 66 92.32 High High
antagonist 8 86.56 High High
metalloproteinase 4 45.60 Quite Low
Inflammation 62 17.68 Low Low
rheumatoid arthritis 70 5.00 Very Low Very Low Very Low
Arthritis 34 5.00 Very Low Very Low Very Low
cytokine 24 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 2 95.92 Very High Very High Very High
Chondroma 82 94.44 High High
Cleidocranial Dysplasia 4 92.96 High High
Osteoarthritis 66 92.32 High High
Enchondromatosis 112 89.60 High High
Congenital Anomalies 12 67.08 Quite High
Calcification 2 64.48 Quite High
Cancer 42 60.08 Quite High
Arthritis 50 50.00 Quite Low
Chondrosarcoma 24 40.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Parathyroid hormone-related protein (PTHrP) and Indian Hedgehog (IHH) acting on their respective receptors PTHR1 and PTCH1 exert a tightly coupled signaling relay, which is critical for the regulation of endochondral ossification (Figure 2).
Regulation (acting) of PTHrP in Parathyroid
1) Confidence 0.24 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1592482 Disease Relevance 0.98 Pain Relevance 0
Parathyroid hormone-related protein (PTHrP) and Indian Hedgehog (IHH) acting on their respective receptors PTHR1 and PTCH1 exert a tightly coupled signaling relay, which is critical for the regulation of endochondral ossification (Figure 2).
Regulation (acting) of Parathyroid hormone-related protein in Parathyroid
2) Confidence 0.24 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1592482 Disease Relevance 0.99 Pain Relevance 0
Furthermore, similar to growth plate development in which hypertrophic maturation is under the regulation of a feedback loop involving Indian hedgehog and parathyroid hormone-related protein (PTHrP) [35], PTHrP also plays a regulatory role in MSC terminal differentiation.
Regulation (regulation) of PTHrP in parathyroid
3) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 0.25 Pain Relevance 0.09
Furthermore, similar to growth plate development in which hypertrophic maturation is under the regulation of a feedback loop involving Indian hedgehog and parathyroid hormone-related protein (PTHrP) [35], PTHrP also plays a regulatory role in MSC terminal differentiation.
Regulation (regulation) of PTHrP in parathyroid
4) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 0.25 Pain Relevance 0.09

General Comments

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