INT197794

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ihh) Golgi apparatus (Pthlh) intracellular (Pthlh)
embryo development (Ihh) cell-cell signaling (Ihh) cytoplasm (Pthlh)
Pthlh (Mus musculus)
Ihh (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 1 11.04 Low Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Enchondromatosis 56 99.60 Very High Very High Very High
Chondroma 41 99.60 Very High Very High Very High
Targeted Disruption 2 98.60 Very High Very High Very High
Cancer 10 97.16 Very High Very High Very High
Cleidocranial Dysplasia 2 73.60 Quite High
Chondrosarcoma 12 55.60 Quite High
Malignant Neoplastic Disease 14 48.56 Quite Low
Congenital Anomalies 6 20.60 Low Low
Multiple Hereditary Exostoses 7 5.00 Very Low Very Low Very Low
Spontaneous Fractures 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because regulation of Ihh by PTHrP was found to be lost in these enchondromas, additional transgenic mice were generated that overexpress the Hedgehog (Hh) transcriptional regulator, Gli2.
Negative_regulation (lost) of PTHrP Regulation (regulation) of Ihh associated with targeted disruption and chondroma
1) Confidence 0.36 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1592482 Disease Relevance 1.33 Pain Relevance 0

General Comments

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