INT19780

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Context Info
Confidence 0.29
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.43
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
nucleus 1
bladder 1
Dbi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 13 98.40 Very High Very High Very High
interstitial cystitis 1 79.56 Quite High
Nerve growth factor 1 74.80 Quite High
narcan 1 48.48 Quite Low
Enkephalin 2 42.48 Quite Low
Opioid 3 37.04 Quite Low
Dynorphin 1 26.80 Quite Low
opioid receptor 2 25.00 Low Low
Bioavailability 4 20.80 Low Low
Kinase C 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 16 98.40 Very High Very High Very High
Cystitis 3 94.52 High High
Interstitial Cystitis 1 79.56 Quite High
Disease 33 5.00 Very Low Very Low Very Low
Cancer 27 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 21 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 17 5.00 Very Low Very Low Very Low
Hepatitis C Virus Infection 12 5.00 Very Low Very Low Very Low
Infection 11 5.00 Very Low Very Low Very Low
Toxicity 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For improved stability, antisense ODN was replaced with antisense peptide nucleic acid (PNA) and its penetration into bladder was facilitated by tethering TAT peptide sequence.
Protein_catabolism (stability) of ODN in bladder
1) Confidence 0.29 Published 2006 Journal Mol. Pharm. Section Abstract Doc Link 16889433 Disease Relevance 0.43 Pain Relevance 0.17
Ten millimolar of ethylenediaminetetra acetic acid (EDTA) completely inhibited the degradation of [125I]beta-EP in the incubation mixture at 4 degrees C, thus making it possible to quantitatively examine the [125I]beta-EP binding.
Protein_catabolism (degradation) of beta-EP
2) Confidence 0.28 Published 1990 Journal Chem. Pharm. Bull. Section Abstract Doc Link 2092936 Disease Relevance 0 Pain Relevance 0
Most of the As-ODN is degraded there and only the small portion that escapes to the cytoplasm and the nucleus is responsible for its pharmacological effects [20, 21].
Protein_catabolism (degraded) of As-ODN in nucleus
3) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0 Pain Relevance 0

General Comments

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