INT197810

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.47
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (MEN1, MUC1) nucleus (MEN1, MUC1) protein binding, bridging (MEN1)
embryo development (MEN1) DNA binding (MEN1) protein complex (MEN1)
Anatomy Link Frequency
Mouse 1
MEN1 (Homo sapiens)
MUC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 14 5.00 Very Low Very Low Very Low
Somatostatin 6 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Endocrine Neoplasia Type 1 208 98.12 Very High Very High Very High
Metastasis 12 70.16 Quite High
Genomic Instability 2 55.20 Quite High
Cancer 118 48.92 Quite Low
Syndrome 50 20.16 Low Low
Carcinoid 26 15.60 Low Low
Gastrinoma 34 5.00 Very Low Very Low Very Low
Hypercalcemia 30 5.00 Very Low Very Low Very Low
Pituitary Cancer 16 5.00 Very Low Very Low Very Low
Pancreatic Cancer 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Even the rodent protein Pem has been shown to bind menin directly [55].
menin Binding (bind) of Pem
1) Confidence 0.06 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 0.15 Pain Relevance 0
Mouse and human menin are very similar and this could suggest the existence of a human protein, with a function similar to that of Pem, which binds menin and thus plays a role in the pathogenicity of MEN1 mutations.
menin Binding (binds) of Pem in Mouse associated with multiple endocrine neoplasia type 1
2) Confidence 0.06 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 0.32 Pain Relevance 0

General Comments

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