INT197825

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.43
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (JUND)
JUND (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 7 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Somatostatin 3 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 5 97.20 Very High Very High Very High
Cancer 61 76.12 Quite High
Obesity 1 63.12 Quite High
Multiple Endocrine Neoplasia Type 1 104 51.88 Quite High
Hyperplasia 7 51.36 Quite High
Death 20 9.04 Low Low
Syndrome 25 5.00 Very Low Very Low Very Low
Gastrinoma 17 5.00 Very Low Very Low Very Low
Hypercalcemia 15 5.00 Very Low Very Low Very Low
Carcinoid 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Wild type menin represses JunD-activated transcription maybe via a histone deacetylase-dependent mechanism [52,53].
Transcription (transcription) of JunD
1) Confidence 0.29 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 0.13 Pain Relevance 0
After 6 h exposure, the transcription regulators JUND, GTF2I and TSC22-D1, which are involved in protection from oxidative stress and lipid/fatty acid metabolism, GPX4, which is involved in protection against oxidative stress, the fatty acid binding protein FABP1, the thrombospondin receptor (or fatty acid translocase) CD36, six acyl-CoA genes and isocitrate dehydrogenase-1 (IDH1), which is one of the more "central" hub proteins were all upregulated.
Transcription (transcription) of JUND associated with stress
2) Confidence 0.19 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.31 Pain Relevance 0

General Comments

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