INT197832

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Context Info
Confidence 0.80
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 11.01
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MEN1) nucleolus (MEN1) nucleus (MEN1)
protein binding, bridging (MEN1) embryo development (MEN1) DNA binding (MEN1)
Anatomy Link Frequency
pituitary 2
nucleus 1
MEN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 7 98.32 Very High Very High Very High
imagery 49 92.80 High High
corticosteroid 7 84.16 Quite High
abdominal pain 7 81.92 Quite High
Dopamine 7 70.80 Quite High
agonist 7 70.08 Quite High
Somatostatin 21 51.60 Quite High
Central nervous system 7 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Endocrine Neoplasia Type 1 728 100.00 Very High Very High Very High
Cancer 413 100.00 Very High Very High Very High
Pituitary Cancer 56 100.00 Very High Very High Very High
Pancreatic Cancer 49 100.00 Very High Very High Very High
Prolactinoma 21 99.52 Very High Very High Very High
Gastrinoma 119 99.40 Very High Very High Very High
Lipoma 35 99.14 Very High Very High Very High
Nasal Tumor 35 98.68 Very High Very High Very High
Meningioma 7 98.56 Very High Very High Very High
Headache 7 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The nuclear localisation of menin suggests that this protein may have an important role in the regulation of DNA transcription and replication, in cell cycle, or in the maintenance of genome integrity.
Localization (localisation) of menin
1) Confidence 0.80 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 0.40 Pain Relevance 0
However, since Pem sequence has no known homolog in the human genome, its direct relevance to MEN1 in humans is still controversial.
Localization (relevance) of MEN1 associated with multiple endocrine neoplasia type 1
2) Confidence 0.75 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 0.24 Pain Relevance 0
These prolactin-secreting tumours are the most common pituitary tumours in MEN1 and they are characterised by the increased serum concentrations of prolactin (reference values: premenopausal women 0–20 ng/ml; postmenopausal women 0–15 ng/ml; men 0–15 ng/ml) [17].
Localization (secreting) of MEN1 in pituitary associated with multiple endocrine neoplasia type 1, cancer and pituitary cancer
3) Confidence 0.75 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 2.33 Pain Relevance 0.27
These gastrin-secreting tumours represent more than 50% of all pancreatic tumours in MEN1.
Localization (secreting) of MEN1 associated with multiple endocrine neoplasia type 1, cancer and pancreatic cancer
4) Confidence 0.75 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 2.69 Pain Relevance 0.15
Cutaneous tumours (angiofibromas, collagenomas, lipomas) may help the presymptomatic diagnosis of MEN1, before manifestations of hormone-secreting tumours appear.


Localization (secreting) of MEN1 associated with multiple endocrine neoplasia type 1, lipoma, nasal tumor and cancer
5) Confidence 0.71 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 2.49 Pain Relevance 0
Approximately 60% of MEN1-associated pituitary tumours secrete prolactin (prolactinomas), 25% secrete growth hormone (GH) causing gigantism in children and acromegaly in adults, 3% secrete adenocorticotrophin (ACTH) causing hypercortisolism, and the others seem to be non-functional.
Localization (secrete) of MEN1-associated in pituitary associated with acromegaly, multiple endocrine neoplasia type 1, gigantism, prolactinoma and pituitary cancer
6) Confidence 0.70 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 2.13 Pain Relevance 0.21
These studies revealed that menin is located primarily in the nucleus [46] and identified at least two independent nuclear localisation signals (NLSs) in the C-terminus of the protein.
Localization (located) of menin in nucleus
7) Confidence 0.65 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 0.56 Pain Relevance 0

General Comments

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