INT197834

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.32
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MEN1) nucleolus (MEN1) nucleus (MEN1)
protein binding, bridging (MEN1) embryo development (MEN1) DNA binding (MEN1)
MEN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 28 44.24 Quite Low
Somatostatin 12 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Endocrine Neoplasia Type 1 416 99.74 Very High Very High Very High
Metastasis 24 99.60 Very High Very High Very High
Genomic Instability 4 98.00 Very High Very High Very High
Cancer 236 90.32 High High
Disease 24 88.16 High High
Syndrome 100 78.64 Quite High
Carcinoid 52 56.40 Quite High
Malignant Neoplastic Disease 12 32.56 Quite Low
Neuroendocrine Cancer 4 31.76 Quite Low
Gastrinoma 68 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, menin interacts with the metastasis suppressor Nm23H1 [56].
menin Binding (interacts) of associated with metastasis
1) Confidence 0.48 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 0.71 Pain Relevance 0
The binding of menin to Nm23H1 may be relevant also to the control of genomic stability, as Nm23H1 is associated to the centrosome that is involved in the maintenance of chromosome integrity.
menin Binding (binding) of associated with genomic instability
2) Confidence 0.37 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 0.96 Pain Relevance 0
An understanding of the function of MEN1 gene and of menin interacting proteins, in the near future, may help correlation studies and assist clinical management of patients.


menin Binding (interacting) of associated with multiple endocrine neoplasia type 1
3) Confidence 0.36 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 1.49 Pain Relevance 0
In the last years menin has been shown to interact with several proteins of known functions.
menin Binding (interact) of
4) Confidence 0.33 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 0.16 Pain Relevance 0

General Comments

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