INT197836

Context Info Confidence 0.50 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 3.16 Pain Relevance 0.07

cytosol (MEN1) nucleolus (MEN1) nucleus (MEN1) protein binding, bridging (MEN1) embryo development (MEN1) DNA binding (MEN1)

Anatomy Link Frequency parathyroid 2 MEN1 (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 1 72.96 depression 1 67.52 imagery 7 5.00 Somatostatin 3 5.00 corticosteroid 1 5.00 abdominal pain 1 5.00 agonist 1 5.00 Dopamine 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Multiple Endocrine Neoplasia Type 1 104 100.00 Hypercalcemia 15 100.00 Hyperplasia 2 96.80 Cancer 59 94.48 Parathyroid Cancer 4 93.88 Insulinoma 6 76.36 Gastrinoma 17 75.76 Carcinoid 13 69.60 Depression 1 67.52 Confusion 1 64.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PHPT in MEN1 manifests with hypercalcaemia as a result of overproduction of parathyroid hormone (PTH) by tumoural and supernumerary parathyroid glands.

Positive_regulation (overproduction) of Gene_expression (overproduction) of MEN1 in parathyroid associated with multiple endocrine neoplasia type 1 and hypercalcemia

1) Confidence 0.50 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 3.16 Pain Relevance 0.07

General Comments

This test has worked.