INT197917

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ESR1, Sh2b2) plasma membrane (ESR1, Sh2b2) nucleoplasm (ESR1)
enzyme binding (ESR1) DNA binding (ESR1) protein complex (ESR1)
Anatomy Link Frequency
MCF-7 1
ESR1 (Homo sapiens)
Sh2b2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 3 79.76 Quite High
agonist 2 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Dysmenorrhea 1 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Breast Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alkylphenols (APs), such as octyl-phenol (OP) and nonylphenol (NP), were reported to bind directly to the ER in trout, stimulate citelogenin gene expression in trout hepatocytes, be mitogenic in MCF-7 cells and stimulate transcription in mammalian cells via ER [12].
ER Binding (bind) of APs in MCF-7
1) Confidence 0.01 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0.04

General Comments

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