INT19795

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2010
Negated 4
Speculated 4
Reported most in Body
Documents 161
Total Number 167
Disease Relevance 103.69
Pain Relevance 11.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
Anatomy Link Frequency
thyroid 3
head 3
lung 3
neck 3
HeLa 2
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 19 99.98 Very High Very High Very High
cocaine 16 99.96 Very High Very High Very High
Cannabinoid 69 99.92 Very High Very High Very High
Opioid 5 99.80 Very High Very High Very High
Kinase C 14 99.58 Very High Very High Very High
metalloproteinase 29 99.56 Very High Very High Very High
bradykinin 12 98.64 Very High Very High Very High
Morphine 11 98.58 Very High Very High Very High
Endocannabinoid 42 98.36 Very High Very High Very High
cINOD 266 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Lung Cancer 682 100.00 Very High Very High Very High
Colorectal Cancer 83 100.00 Very High Very High Very High
Adenocarcinoma 171 99.92 Very High Very High Very High
Cancer 5114 99.88 Very High Very High Very High
Prostate Cancer 209 99.80 Very High Very High Very High
Disease 1502 99.76 Very High Very High Very High
Carcinoma 143 99.76 Very High Very High Very High
Hepatocellular Cancer 27 99.76 Very High Very High Very High
Glioma 775 99.64 Very High Very High Very High
Bladder Cancer 74 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a first study [12], an increase in EGFR copy number identified by FISH (fluorescence in situ hybridization) was found in all but one responding patients, while four recent studies identified no or few cetuximab responders in KRAS mutated patients [13-17].
Positive_regulation (increase) of EGFR
1) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2432064 Disease Relevance 0.41 Pain Relevance 0
In a study involving 31 patients[12], Moroni et al observed an increase in EGFR copy number in 8 of the 9 cetuximab-responders but only in 1 of the 20 nonresponder patients who were assessable by FISH, suggesting that this increase may represent a strong positive predictive factor for response to this compound.
Positive_regulation (increase) of EGFR
2) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2432064 Disease Relevance 0.19 Pain Relevance 0
Tumors showing high polysomy and/or gene amplification were considered to be FISH positive and as significant increases in EGFR copy number.


Positive_regulation (increases) of EGFR associated with cancer
3) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2432064 Disease Relevance 0.64 Pain Relevance 0
Of note, an authentic amplification was found in 7 of these 9 patients with increased EGFR copy number.
Positive_regulation (increased) of EGFR
4) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2432064 Disease Relevance 0.22 Pain Relevance 0
Furthermore, regarding the significant number of responding patients without any significant increase in EGFR copy number in both Lievre et al's study (8 out of 11 responders) and ours (7 out of 9 responders), we do not believe that this parameter should be considered as a prerequisite for cetuximab activity.


Neg (without) Positive_regulation (increase) of EGFR
5) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2432064 Disease Relevance 0.26 Pain Relevance 0
Thus, a significant increase in EGFR copy number may be associated with a high probability of response, even though this molecular alteration may be relatively rare in mCRC.
Positive_regulation (increase) of EGFR
6) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2432064 Disease Relevance 0.15 Pain Relevance 0
An increased EGFR copy number was noted in 12 patients (Table 2), but was considered as significant in only 2 patients, corresponding to high polysomy (patients 1 and 3, Figure 1).
Positive_regulation (increased) of EGFR
7) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2432064 Disease Relevance 0.26 Pain Relevance 0
In one of these studies which is consistent with our own results, only 3 patients out of 30 displayed an increase in EGFR copies as evaluated by CISH [13]; these 3 patients responded to cetuximab.
Positive_regulation (increase) of EGFR
8) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2432064 Disease Relevance 0.16 Pain Relevance 0
The FISH analysis was able to detect an increase in the EGFR gene and number of chromosome 7 copies which correlated with specific EGFR mutations.
Positive_regulation (increase) of EGFR gene
9) Confidence 0.69 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721286 Disease Relevance 0.55 Pain Relevance 0
Expression of EGFR is exaggerated in pancreatic adenocarcinoma and activation of EGFR appears to have an important role in the growth and differentiation of this and other types of cancers.
Positive_regulation (activation) of EGFR associated with adenocarcinoma and cancer
10) Confidence 0.69 Published 2007 Journal Cancer Invest. Section Abstract Doc Link 18027154 Disease Relevance 0.59 Pain Relevance 0.08
Cigarette smoke causes both mucus hypersecretion and increases the number of goblet cells through activation of the EGFR system [32].
Positive_regulation (activation) of EGFR in goblet cells
11) Confidence 0.69 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 1.14 Pain Relevance 0.10
Therefore, EGFR activation may play a role in epithelial phenotypic alterations observed in COPD through active smoking.
Positive_regulation (activation) of EGFR associated with nicotine addiction and pulmonary disease
12) Confidence 0.69 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 2.09 Pain Relevance 0.04
A wide variety of stimuli can induce EGFR activation in vitro and in animals, including cigarette smoke [7,8].
Positive_regulation (activation) of EGFR
13) Confidence 0.69 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 1.85 Pain Relevance 0
activation of the receptor and consequently the induction of the EGFR signaling
Positive_regulation (induction) of EGFR
14) Confidence 0.69 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0 Pain Relevance 0
Binding to ligands induces EGFR homo-or heterodimerization
Positive_regulation (induces) of EGFR
15) Confidence 0.69 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.23 Pain Relevance 0
Transactivation of the EGFR mediates endothelin-1 (a powerful vasoconstrictor, involving in vasospastic diseases such as coronary artery disease) signaling in vascular smooth muscle cells and isolated arteries [41].
Positive_regulation (Transactivation) of EGFR in smooth muscle cells associated with coronary artery disease and disease
16) Confidence 0.69 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2515827 Disease Relevance 1.03 Pain Relevance 0.07
A second hypothesis for this synergy is that treatment with paclitaxel may upregulate EGFR receptors in tumor cells, making cells more susceptible to anti-EGFR therapies.
Spec (may) Positive_regulation (upregulate) of EGFR associated with cancer
17) Confidence 0.68 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886327 Disease Relevance 0.70 Pain Relevance 0.04
In breast adenocarcinoma cell lines, activation of the EGFR pathway is linked to activation of the multidrug resistance transporter family.61 EGFR resistance may also be due to mutations in the receptor protein itself.
Positive_regulation (activation) of EGFR associated with adenocarcinoma
18) Confidence 0.68 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886327 Disease Relevance 0.63 Pain Relevance 0.03
EGFR is overexpressed in about 40% to 80% of NSCLC.28 Downstream signaling by the activated EGFR can be abrogated by small molecule inhibitors, such as erlotinib and gefitinib or by monoclonal antibodies directed towards the extracellular domain of EGFR, such as cetuximab.
Positive_regulation (activated) of EGFR associated with non-small-cell lung cancer
19) Confidence 0.68 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886327 Disease Relevance 0.63 Pain Relevance 0.07
Treatment of HDS cells with EGF produced a significant increase in the levels of activated EGFR which was not observed in the presence of gefitinib.
Positive_regulation (activated) of EGFR
20) Confidence 0.68 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947117 Disease Relevance 0.30 Pain Relevance 0.07

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