INT197969

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Context Info
Confidence 0.72
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 3.39
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prdx5) oxidoreductase activity (Prdx5) peroxisome (Prdx5)
cytoplasm (Prdx5)
Anatomy Link Frequency
immune cells 2
THP-1 1
epithelial cells 1
Calu-3 1
band 1
Prdx5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 320 96.64 Very High Very High Very High
cytokine 24 67.08 Quite High
anesthesia 8 41.12 Quite Low
Disease Link Frequency Relevance Heat
Hypersensitivity 16 97.24 Very High Very High Very High
INFLAMMATION 304 96.64 Very High Very High Very High
Acute Monocytic Leukemia 8 96.40 Very High Very High Very High
Asthma 8 95.96 Very High Very High Very High
Necrosis 8 93.00 High High
Cancer 8 92.64 High High
Hyperoxia 8 88.80 High High
Hypoxia 24 83.20 Quite High
Lung Cancer 8 82.88 Quite High
Pneumonia 24 80.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PRXV gene is located on human chromosome 11q13, which is a region of genetic linkage for atopic hypersensitivity such as bronchial asthma.
Localization (located) of PRXV gene associated with asthma and hypersensitivity
1) Confidence 0.72 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.75 Pain Relevance 0.03
Our third aim was to determine in vitro whether exposure of the airway and alveolar epithelial cells to live bacteria, either alone or in co-culture with murine macrophages RAW264.7 changes the level of PRXV mRNA as well as protein expression and secretion.
Localization (secretion) of PRXV mRNA in epithelial cells
2) Confidence 0.72 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.49 Pain Relevance 0.27
In studies of secreted PRXV, we observed only a 60 kDa band by Western blot analyses.
Localization (secreted) of PRXV in band
3) Confidence 0.67 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.83 Pain Relevance 0.14
PRXV was secreted in vitro by both the epithelial and immune cells.
Localization (secreted) of PRXV in immune cells
4) Confidence 0.67 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.36 Pain Relevance 0.18
Finally, using Western blot analyses of cell-conditioned medium with and without serum, we studied the presence of PRXV in the cell secretions of all cell lines that we used.
Localization (secretions) of PRXV
5) Confidence 0.63 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.15 Pain Relevance 0.04
Calu-3 and THP-1 secreted the monomeric form of PRXV into the medium (Figure 6A).
Localization (secreted) of PRXV in THP-1
6) Confidence 0.59 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.24 Pain Relevance 0.07
PRXV was secreted in vitro by epithelial and immune cells.


Localization (secreted) of PRXV in immune cells
7) Confidence 0.59 Published 2006 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1601951 Disease Relevance 0.32 Pain Relevance 0.16
Calu-3 and THP-1 secreted the monomeric form of PRXV into the medium (Figure 6A).
Localization (secreted) of PRXV in Calu-3
8) Confidence 0.20 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.24 Pain Relevance 0.07

General Comments

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