INT197979

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Context Info
Confidence 0.23
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.14
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Prdx1) cytosol (Prdx1) mitochondrion (Prdx1)
oxidoreductase activity (Prdx1) nucleolus (Prdx1) nucleus (Prdx1)
Anatomy Link Frequency
B lymphocytes 1
lung 1
Prdx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 82 99.32 Very High Very High Very High
cytokine 10 87.16 High High
chemokine 10 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 2 99.44 Very High Very High Very High
INFLAMMATION 78 99.32 Very High Very High Very High
Hypersensitivity 4 99.06 Very High Very High Very High
Hyperoxia 2 98.04 Very High Very High Very High
Multiple Myeloma 14 97.88 Very High Very High Very High
Lymphatic System Cancer 244 97.32 Very High Very High Very High
Apoptosis 18 88.44 High High
Cancer 84 88.08 High High
Necrosis 2 87.60 High High
T-cell Lymphoma 42 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Allergic inflammation in response to ovalbumin induced overexpression of PRXI [22], which is also well known to be induced by hyperoxia [23].
Gene_expression (overexpression) of PRXI associated with inflammation, hyperoxia and hypersensitivity
1) Confidence 0.23 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.88 Pain Relevance 0.17
Prior studies of PRX expression showed that PRXI, II, III, V and VI are highly over-expressed in the human lung cancer cells [21].
Gene_expression (expressed) of PRXI in lung associated with lung cancer
2) Confidence 0.23 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.87 Pain Relevance 0.17
Damasi et al., after demonstrating that peroxiredoxin I (PrdxI) is expressed in plasma cells but not in B lymphocytes, analyzed eight cases of PBL and nine of MM by immunohistochemistry.
Neg (not) Gene_expression (expressed) of PrdxI in B lymphocytes associated with lymphatic system cancer and multiple myeloma
3) Confidence 0.18 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.15 Pain Relevance 0
The results show that that PrdxI expression is closely connected with the immunoglobulin production capacity of the cells, which means high in MM, but absent in PBL cases, except one, wherein few cells were stained.
Gene_expression (expression) of PrdxI associated with lymphatic system cancer and multiple myeloma
4) Confidence 0.18 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.23 Pain Relevance 0

General Comments

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