INT19798

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Context Info
Confidence 0.41
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.37
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
spinal cord 2
microglia 2
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 4 99.58 Very High Very High Very High
Spinal cord 2 99.08 Very High Very High Very High
antinociception 5 98.80 Very High Very High Very High
Inflammation 11 95.84 Very High Very High Very High
Hyperalgesia 8 89.84 High High
agonist 12 88.16 High High
Morphine 3 87.04 High High
Potency 1 80.28 Quite High
Antinociceptive 1 75.00 Quite High
dorsal root ganglion 32 74.08 Quite High
Disease Link Frequency Relevance Heat
Nociception 29 98.80 Very High Very High Very High
INFLAMMATION 12 95.84 Very High Very High Very High
Hyperalgesia 8 89.84 High High
Neuroblastoma 2 75.36 Quite High
Ganglion Cysts 33 74.08 Quite High
Stroke 23 72.20 Quite High
Inflammatory Pain 2 59.36 Quite High
Drug Induced Neurotoxicity 5 50.00 Quite Low
Hematoma 1 50.00 Quite Low
Pressure And Volume Under Development 1 48.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of the antinociception induced by it injected calcium channel blockers appears to depend on the interaction of the drugs with Ca2+ binding sites in the spinal cord and, probably, on the type of voltage-sensitive calcium channel involved.
Spec (probably) Positive_regulation (depend) of Ca2 Binding (interaction) of in spinal cord associated with antinociception, calcium channel and spinal cord
1) Confidence 0.41 Published 1990 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 2094542 Disease Relevance 0 Pain Relevance 0.88
Importantly for this study, lipopolysaccharide (LPS) increases Ca2+ in microglia and activates p38 MAPK and NF-?
Positive_regulation (increases) of Ca2 Binding (microglia) of in microglia
2) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.29 Pain Relevance 0.05
TRPV4-Ct forms a Ca2+-sensitive supra-molecular signaling complex made of actin, tubulin as well as nociceptive signaling components PKC?
Positive_regulation (made) of Ca2 Binding (complex) of associated with nociception
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.54 Pain Relevance 0.31
TRPV4-Ct forms a Ca2+-sensitive supra-molecular signaling complex made of actin, tubulin as well as nociceptive signaling components PKC?
Positive_regulation (supra) of Ca2 Binding (complex) of associated with nociception
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.54 Pain Relevance 0.31

General Comments

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