INT197982

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2006
Negated 4
Speculated 0
Reported most in Body
Documents 1
Total Number 19
Disease Relevance 6.27
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prdx5) oxidoreductase activity (Prdx5) peroxisome (Prdx5)
cytoplasm (Prdx5)
Anatomy Link Frequency
epithelial cells 14
leukocytes 8
A549 8
macrophages 2
Calu-3 2
Prdx5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 760 99.98 Very High Very High Very High
cytokine 57 98.64 Very High Very High Very High
anesthesia 19 50.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 722 99.98 Very High Very High Very High
Pneumonia 57 99.82 Very High Very High Very High
Toxicity 38 83.60 Quite High
Acute Monocytic Leukemia 19 68.60 Quite High
Apoptosis 76 45.80 Quite Low
Lung Injury 38 38.80 Quite Low
Injury 19 36.76 Quite Low
Pulmonary Disease 19 29.72 Quite Low
Stress 76 28.32 Quite Low
Hypoxia 57 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In primary airway cell culture (cow) and alveolar epithelial cells A549, or co-culture of the epithelial cells with murine macrophages RAW264.7, exposure to live bacteria mildly, yet significantly, increased expression of PRXV protein.
Positive_regulation (increased) of Gene_expression (expression) of PRXV protein in macrophages
1) Confidence 0.67 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.46 Pain Relevance 0.20
Therefore, infiltration of the lung parenchyma with leukocytes resulted in an enhanced overall expression of PRXV at sites of inflammation.

2.

Positive_regulation (enhanced) of Gene_expression (expression) of PRXV in leukocytes associated with inflammation
2) Confidence 0.58 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.48 Pain Relevance 0.21
We found that both in vivo and in vitro inflammation induced by bacteria resulted in an increased expression of PRXV in the airway epithelium by at least 2 different mechanisms: massive influx of activated leukocytes, which highly express PRXV, and moderate translational up-regulation of PRXV in the epithelial cells.


Positive_regulation (resulted) of Gene_expression (expression) of PRXV in epithelial cells associated with inflammation
3) Confidence 0.58 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.37 Pain Relevance 0.23
Similarly, we did not observe a significant increase in PRXV expression in the cells of alveolar epithelial lining during inflammation.
Positive_regulation (increase) of Gene_expression (expression) of PRXV associated with inflammation
4) Confidence 0.58 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.55 Pain Relevance 0.24
Western blot analyses demonstrated that co-culture of A549 with RAW264.7 and stimulation with PAO1 resulted in enhanced expression of PRXV only in the presence of serum, as shown in Figure 3.
Positive_regulation (resulted) of Gene_expression (expression) of PRXV in A549
5) Confidence 0.58 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.11 Pain Relevance 0.06
In the presence of serum, the addition of live P. aeruginosa modestly increased PRXV expression in A549 cultures, as well as in co-cultures with RAW264.7.
Positive_regulation (increased) of Gene_expression (expression) of PRXV in A549
6) Confidence 0.58 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0 Pain Relevance 0
Unlike Calu-3, the primary cultures of cow tracheal epithelium showed a pattern of increased PRXV expression after exposure to bacteria which was similar to the pattern shown by the A549 cells (Figure 5C).
Positive_regulation (increased) of Gene_expression (expression) of PRXV in Calu-3
7) Confidence 0.58 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.12 Pain Relevance 0.03
However, neither PRXV protein expression nor PRXV mRNA levels changed after exposure to PAO1; the mean relative PRXV protein expression following exposure to PAO1 was 106 ± 25% in the presence of serum and 76 ± 22% without serum as compared to baseline (Figure 5A).
Neg (nor) Positive_regulation (changed) of Gene_expression (expression) of PRXV mRNA
8) Confidence 0.45 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0 Pain Relevance 0
In vivo and in vitro bacterial inflammation mildly up-regulates expression of PRXV protein in the airway epithelial cells.
Positive_regulation (regulates) of Gene_expression (expression) of PRXV protein in epithelial cells associated with inflammation
9) Confidence 0.45 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.35 Pain Relevance 0.17
In rats, neither the presence of endotoxins nor f-MLP-induced migration of leukocytes in the tracheal epithelium changed mRNA levels of PRXV; f-MLP slightly increased expression of PRXV protein in the tracheal epithelium.
Positive_regulation (increased) of Gene_expression (expression) of PRXV protein in epithelium
10) Confidence 0.45 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.42 Pain Relevance 0.17
Bacterial lung inflammation did not change expression of PRXV in murine epithelia but produced massive influx of leukocytes highly expressing PRXV.
Neg (not) Positive_regulation (change) of Gene_expression (expression) of PRXV in leukocytes associated with inflammation and pneumonia
11) Confidence 0.39 Published 2006 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1601951 Disease Relevance 0.32 Pain Relevance 0.16
We found that both in vivo and in vitro inflammation induced by bacteria resulted in an increased expression of PRXV in the airway epithelium by at least 2 different mechanisms: massive influx of activated leukocytes, which highly express PRXV, and moderate translational up-regulation of PRXV in the epithelial cells.


Positive_regulation (increased) of Gene_expression (expression) of PRXV in epithelial cells associated with inflammation
12) Confidence 0.39 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.36 Pain Relevance 0.23
Inflammation increased expression of PRXV in airways by at least 2 mechanisms: cell population shift by massive influx of leukocytes expressing PRXV, and moderate post-transcriptional up-regulation of PRXV in epithelial cells.



Positive_regulation (increased) of Gene_expression (expression) of PRXV in leukocytes associated with inflammation
13) Confidence 0.39 Published 2006 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1601951 Disease Relevance 0.32 Pain Relevance 0.16
However, experiments in vitro in which pro-inflammatory cytokines were added to human alveolar or bronchial epithelial cells did not result in an up-regulated expression of PRXV [18].
Neg (not) Positive_regulation (result) of Gene_expression (expression) of PRXV in epithelial cells associated with inflammation and cytokine
14) Confidence 0.39 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.64 Pain Relevance 0.30
In primary airway cell culture (cow), alveolar epithelial cells A549, or co-culture of A549 with murine macrophages RAW264.7, exposure to live bacteria increased expression of PRXV, which required serum.
Positive_regulation (increased) of Gene_expression (expression) of PRXV in A549
15) Confidence 0.39 Published 2006 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1601951 Disease Relevance 0.32 Pain Relevance 0.16
An increased influx of activated leukocytes to inflamed tissues serves as a source of enhanced expression of PRXV in the lung.


Positive_regulation (enhanced) of Gene_expression (expression) of PRXV in leukocytes
16) Confidence 0.39 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.32 Pain Relevance 0.16
However, experiments in vitro in which pro-inflammatory cytokines were added to human alveolar or bronchial epithelial cells did not result in an up-regulated expression of PRXV [18].
Positive_regulation (regulated) of Gene_expression (expression) of PRXV in epithelial cells associated with inflammation and cytokine
17) Confidence 0.39 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.64 Pain Relevance 0.30
Western blot analyses demonstrated that co-culture of A549 with RAW264.7 and stimulation with PAO1 resulted in enhanced expression of PRXV only in the presence of serum, as shown in Figure 3.
Positive_regulation (enhanced) of Gene_expression (expression) of PRXV in A549
18) Confidence 0.39 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.11 Pain Relevance 0.06
In the f-MLP model of inflammation, a 4-hour exposure of the isolated tracheal segment to f-MLP provided a small (32%) yet significant (p < 0.05) increase in the PRXV expression in the cells of tracheal epithelium (from 182 ± 16 relative units in the control to 241 ± 3 relative units in the experimental group), but not in mRNA levels (2.36 ± 0.23 in the control versus 1.51 ± 0.22 in the experimental group).
Neg (not) Positive_regulation (increase) of Gene_expression (expression) of PRXV in epithelium associated with inflammation
19) Confidence 0.39 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.37 Pain Relevance 0.18

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