INT19799

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Context Info
Confidence 0.48
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 71
Total Number 72
Disease Relevance 13.69
Pain Relevance 12.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
pore 4
astrocytes 3
synapse 2
heart 2
internal 2
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 239 100.00 Very High Very High Very High
imagery 141 100.00 Very High Very High Very High
opioid receptor 73 99.98 Very High Very High Very High
TRP channel 89 99.90 Very High Very High Very High
nMDA receptor 320 99.76 Very High Very High Very High
lidocaine 3 99.64 Very High Very High Very High
opiate 11 99.32 Very High Very High Very High
Calcium channel 27 99.30 Very High Very High Very High
agonist 169 99.22 Very High Very High Very High
Spinal cord 88 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 237 100.00 Very High Very High Very High
Channelopathies 8 99.92 Very High Very High Very High
Autolysis 3 99.40 Very High Very High Very High
Hypoxia 695 99.12 Very High Very High Very High
Li-fraumeni Syndrome 85 99.12 Very High Very High Very High
Injury 87 99.00 Very High Very High Very High
Nociception 104 98.60 Very High Very High Very High
Convulsion 54 96.60 Very High Very High Very High
INFLAMMATION 48 95.84 Very High Very High Very High
Targeted Disruption 69 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The studies suggest that opiates in vivo can alter [3H]nimodipine binding to the Ca2+ channel receptor protein.
Ca2 Binding (binding) of associated with opiate
1) Confidence 0.48 Published 1988 Journal Neurochem. Res. Section Abstract Doc Link 2853309 Disease Relevance 0 Pain Relevance 0.71
Simple interpretation of changes in Ca2+ transient kinetics is complicated by the interaction of some Ca2+ transport mechanisms with changes in membrane potential during the action potential.
Ca2 Binding (interaction) of associated with action potential
2) Confidence 0.40 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.27 Pain Relevance 0.12
Ca2+ overload is a major cause of myocardial cell damage and cardiac dysfunction in ischemic hearts, and Ca2+ overload evoked by reperfusion is associated with irreversible myocardial injury [4].
Ca2 Binding (associated) of in hearts associated with injury
3) Confidence 0.36 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872865 Disease Relevance 0.44 Pain Relevance 0.32
Anoxia also significantly reduced Ca2+ clearance via both the SERCA and PMCA and substantially slowed Ca2+ recycling from the mitochondrion (probably as a consequence of inhibition of SERCA and PMCA).
Ca2 Binding (recycling) of associated with hypoxia
4) Confidence 0.32 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.18 Pain Relevance 0
The mean values obtained for Rmin, Rmax, and (Sf2/Sb2) were then used to calibrate measurements of the fluorescence ratio in subsequent experiments using the equation [Ca2+] = (R ?
Ca2 Binding (equation) of
5) Confidence 0.32 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0 Pain Relevance 0
The present study has been focused on the mechanisms that modify Ca2+ transient generation, which depends directly on the following factors:
Ca2 Binding (generation) of
6) Confidence 0.31 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 1.01 Pain Relevance 0.05
The extremely low level to which [Ca2+]o sinks during SD, and its two-phase recovery, indicate intracellular sequestration or binding of substantial amounts of Ca2+ ions.
Ca2 Binding (binding) of associated with depression
7) Confidence 0.31 Published 1993 Journal Brain Res. Section Abstract Doc Link 8319090 Disease Relevance 0.38 Pain Relevance 0.27
The effects of a kappa opiate agonist have been evaluated on [3H]nimodipine binding to dihydropyridine receptors for 'L'-type Ca2+ channels in rat brain regions.
Ca2 Binding (binding) of in brain associated with agonist and opiate
8) Confidence 0.31 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2841143 Disease Relevance 0 Pain Relevance 0.31
The mechanism of the antinociception induced by it injected calcium channel blockers appears to depend on the interaction of the drugs with Ca2+ binding sites in the spinal cord and, probably, on the type of voltage-sensitive calcium channel involved.
Ca2 Binding (interaction) of in spinal cord associated with antinociception, calcium channel and spinal cord
9) Confidence 0.31 Published 1990 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 2094542 Disease Relevance 0 Pain Relevance 0.88
Neonatal rat ventricular myocytes were obtained from 2- to 4-day-old rats, and electrically induced fluctuations of cytosolic free Ca2+ concentration ([Ca2+]i) in single cardiomyocytes were investigated using spectrofluorometric analysis of fura-2-[Ca2+]i binding.
Ca2 Binding (binding) of in cardiomyocytes
10) Confidence 0.31 Published 1996 Journal Arch. Toxicol. Section Abstract Doc Link 8825672 Disease Relevance 0.07 Pain Relevance 0
Entry of extracellular free Ca2+ through voltage gated Ca2+ channel on astrocytes is also unlikely because astrocytic membrane potential in vivo is retained below ?
Ca2 Binding (Entry) of in astrocytes
11) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424136 Disease Relevance 0 Pain Relevance 0.43
Entry of extracellular free Ca2+ through voltage gated Ca2+ channel on astrocytes is also unlikely because astrocytic membrane potential in vivo is retained below ?
Ca2 Binding (Entry) of in astrocytes
12) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424136 Disease Relevance 0 Pain Relevance 0.44
Cd2+ binding to Fura-2 has similar effects on its fluorescence to those of Ca2+ binding but Fura-2 has a much greater affinity for Cd2+ than for Ca2+ [36].
Ca2 Binding (binding) of
13) Confidence 0.31 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.05 Pain Relevance 0.49
The effects of anoxia on Ca2+ clearance lead to some interesting interactions between the various sources and sinks of Ca2+ within the cell.
Ca2 Binding (interactions) of associated with hypoxia
14) Confidence 0.30 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.48 Pain Relevance 0
Pretreatment of mast cells with lidocaine, an inhibitor of Ca2+ binding to phospholipid, or with nordihydroguaiaretic acid, an inhibitor of Ca2+ flux and lipoxygenase, stimulated arachidonic acid-induced histamine release.
Ca2 Binding (binding) of in mast cells associated with lidocaine
15) Confidence 0.30 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6203535 Disease Relevance 0 Pain Relevance 0.10
These results suggest that exogenous arachidonic acid or its metabolite(s) may interact with membrane-associated Ca2+, disturbing Ca2+ availability for the trigger mechanism of compd 48/80-induced histamine release or inhibiting the subsequent metabolism of arachidonic acid via the lipoxygenase pathway to form active metabolites involved in the histamine liberating mechanism.
Ca2 Binding (interact) of
16) Confidence 0.30 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6203535 Disease Relevance 0 Pain Relevance 0.08
Antibodies that specifically recognize the alpha1 subunits of class A, B, C, D, and E Ca2+ channels have been used to investigate the localization of these voltage-gated ion channels on spinal motor neurons, interneurons, and nerve terminals of the adult rat.
Ca2 Binding (recognize) of in interneurons
17) Confidence 0.30 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9698323 Disease Relevance 0 Pain Relevance 0
Because U50488H inhibits L-type Ca2+ currents in guinea pig ventricular myocytes without OR binding involvement [9] and U50488H increases [Ca2+]i in isolated rat ventricular myocytes, an effect that is antagonized by ?
Ca2 Binding (binding) of in myocytes associated with opioid receptor
18) Confidence 0.28 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872865 Disease Relevance 0.08 Pain Relevance 0.29
Over all, delta binding was greatest in CA2 followed by CA3 and then CA1.
CA2 Binding (binding) of
19) Confidence 0.27 Published 1986 Journal J. Comp. Neurol. Section Abstract Doc Link 3007584 Disease Relevance 0 Pain Relevance 0.42
It appears as if [Ca2+]i overload is a recognized common pathway that underlies myocardial I/R injury [17].
Ca2 Binding (recognized) of associated with injury
20) Confidence 0.27 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872865 Disease Relevance 0.47 Pain Relevance 0.13

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