INT19800

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Context Info
Confidence 0.51
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.20
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Mb)
Anatomy Link Frequency
heart 2
skeletal muscle 1
cleavage 1
Mb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 1 100.00 Very High Very High Very High
Angina 3 96.84 Very High Very High Very High
cytokine 8 80.52 Quite High
Enkephalin 1 80.16 Quite High
Inflammation 4 80.12 Quite High
Spinal cord 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 6 99.28 Very High Very High Very High
Myocardial Infarction 4 99.28 Very High Very High Very High
Cv General 3 Under Development 2 96.84 Very High Very High Very High
Frailty 44 93.16 High High
Cancer 148 92.52 High High
Hypertrophy 10 86.08 High High
Stress 2 82.76 Quite High
INFLAMMATION 4 80.12 Quite High
Disease 6 77.88 Quite High
Appetite Loss 30 75.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MB folds into a helix-hairpin structure when oxidized, and is stabilized by disulfide connectivity between Cys-8 and Cys-40 and Cys-11 and Cys-34 (residue numbers refer to the MB sequence in Fig. 2B).
Protein_catabolism (stabilized) of MB
1) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2805716 Disease Relevance 0 Pain Relevance 0
In the context of developing fully-synthetic lipid/peptide preparations for treating surfactant deficiencies, it is noteworthy that MB and DEPN-8 mixtures were fully resistant to degradation by phospholipase A2 [16].
Protein_catabolism (degradation) of MB
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2805716 Disease Relevance 0 Pain Relevance 0
Certainly, adaptation to MHC isoform composition and metabolism may occur independently [14], but one possible explanation for this transition toward a more fatigable profile may be due, in part, to ATP-independent degradation of myoglobin.


Protein_catabolism (degradation) of myoglobin
3) Confidence 0.44 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 0.68 Pain Relevance 0.06
However, myoglobin, the primary oxygen-carrying protein primarily expressed in oxidative skeletal muscle, appears to be primarily degraded by ATP-independent proteolytic mechanisms [24].
Neg (independent) Protein_catabolism (degraded) of myoglobin in skeletal muscle
4) Confidence 0.44 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 1.07 Pain Relevance 0.08
ELISA using the test systems and a complex of equipment manufactured by Flow Company was employed to study over time the content of fibronectin, fibrinogen, products of its degradation and myoglobin in 178 patients suffering from coronary heart disease (stable and progressive angina pectoris, acute myocardial infarction).
Protein_catabolism (degradation) of myoglobin in heart associated with angina, coronary artery disease and myocardial infarction
5) Confidence 0.32 Published 1990 Journal Ter. Arkh. Section Abstract Doc Link 2095000 Disease Relevance 0.59 Pain Relevance 0.10
[The content of fibronectin, fibrinogen, its degradation products and myoglobin in patients with ischemic heart disease].
Protein_catabolism (degradation) of myoglobin in heart associated with coronary artery disease
6) Confidence 0.21 Published 1990 Journal Ter. Arkh. Section Title Doc Link 2095000 Disease Relevance 0.60 Pain Relevance 0.09
Reproducible product patterns consistent with cleavage of the peptide bond at proline for angiotensin I, Lys-bradykinin, and myoglobin are demonstrated using capillary electrophoresis.
Protein_catabolism (cleavage) of myoglobin in cleavage associated with bradykinin
7) Confidence 0.14 Published 2007 Journal Anal. Chem. Section Abstract Doc Link 17297930 Disease Relevance 0 Pain Relevance 0.13
[Early detection of successful reperfusion by analysis of serum myoglobin in patients with acute myocardial infarction].
Protein_catabolism (analysis) of serum myoglobin associated with myocardial infarction
8) Confidence 0.08 Published 1990 Journal Rinsho Byori Section Title Doc Link 2262975 Disease Relevance 0.25 Pain Relevance 0.06

General Comments

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