INT198005

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Context Info
Confidence 0.24
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.04
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BID, MCL1) cytoplasm (BID, MCL1) cell differentiation (MCL1)
nucleoplasm (MCL1) cytosol (BID) nucleus (MCL1)
BID (Homo sapiens)
MCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 4 42.68 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 216 100.00 Very High Very High Very High
Carcinoma 188 96.44 Very High Very High Very High
Leukemia 8 76.32 Quite High
Cancer 42 75.52 Quite High
Multiple Myeloma 6 73.52 Quite High
Lung Cancer 6 71.76 Quite High
Metastasis 2 69.12 Quite High
Colon Cancer 4 68.00 Quite High
Disease 2 62.16 Quite High
Malignant Neoplastic Disease 2 56.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An important mode of action of Mcl-1 is the interaction with pro-apoptotic Bcl-2 family members (such as Bim [60], Bak, Bid and Bax).
Bid Binding (interaction) of Mcl-1 associated with apoptosis
1) Confidence 0.24 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.83 Pain Relevance 0
Furthermore, Mcl-1 interacts with truncated Bid and, thereby, inhibits intrinsic as well as extrinsic apoptotic signaling [16].
Bid Binding (interacts) of Mcl-1 associated with apoptosis
2) Confidence 0.20 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.21 Pain Relevance 0

General Comments

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